|
Gene id |
2322 |
| Gene Summary Protein Summary Gene ontology KEGG pathways Diseases PubMed |
Gene Summary
|
|
Gene Symbol |
FLT3 Gene UCSC Ensembl |
|
Aliases |
CD135, FLK-2, FLK2, STK1 |
|
Gene name |
fms related receptor tyrosine kinase 3 |
|
Alternate names |
receptor-type tyrosine-protein kinase FLT3, CD135 antigen, FL cytokine receptor, fetal liver kinase 2, fms related tyrosine kinase 3, fms-like tyrosine kinase 3, growth factor receptor tyrosine kinase type III, stem cell tyrosine kinase 1, |
|
Gene location |
13q12.2 (28100586: 28003273) Exons: 27 NC_000013.11
|
|
Gene summary(Entrez) |
This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane le
|
|
OMIM |
136351 |
Protein Summary
|
|
| GO accession | Term name | Evidence code | Go category |
|---|
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|
|
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| Associated diseases |
References |
| Acute myeloid leukemia | KEGG: H00003 |
| Cancer | GAD: 20039765 |
| Osteoporosis | GAD: 17620055 |
| Endometriosis | INFBASE: 27128987 |
| Female infertility | INFBASE: 27128987 |
| Aberrant CpGs in Low Motility Sperm | MIK: 21674046 |
| Cryptorchidism | MIK: 28606200 |
| Male infertility | MIK: 30553232 |
|
|
| PMID |
Condition |
Mutation |
Ethnicity |
Population details |
Infertility_type |
Associated_genes |
Abstract |
| 30553232 |
Male infer
tility
|
|
|
|
Male infertility |
|
Show abstract |
| 21674046 |
Aberrant C
pGs in Low
Motility
Sperm
|
|
|
18
|
Male infertility |
GSE26881
|
Show abstract |
| 28606200 |
Cryptorchi
dism
|
|
|
Monozgotic twin
s (1 control, I
cwith cryptorc
hidism)
|
Male infertility |
MeDIP-Seq
|
Show abstract |
|