• Gene id: 23217

Gene Summary

• Gene Symbol: ZFR2   Gene   UCSC   Ensembl
• Aliases: KIAA1086
• Gene name: zinc finger RNA binding protein 2
• Alternate names: zinc finger RNA-binding protein 2,
• Gene location: 19p13.3 (3869037: 3804023)     Exons: 21     NC_000019.10
• OMIM: 0

Protein Summary

• Protein general information: Q9UPR6  
  • Name: Zinc finger RNA binding protein 2
  • Length: 939  
  • Mass: 101330
• Sequence:

  MATSQYFDFAQGGGPQYSAQPPTLPLPTVGASYTAQPTPGMDPAVNPAFPPAAPAGYGGYQPHSGQDFAYGSRPQ
  EPVPTATTMATYQDSYSYGQSAAARSYEDRPYFQSAALQSGRMTAADSGQPGTQEACGQPSPHGSHSHAQPPQQA
  PIVESGQPASTLSSGYTYPTATGVQPESSASIVTSYPPPSYNPTCTAYTAPSYPNYDASVYSAASPFYPPAQPPP
  PPGPPQQLPPPPAPAGSGSSPRADSKPPLPSKLPRPKAGPRQLQLHYCDICKISCAGPQTYREHLGGQKHRKKEA
  AQKTGVQPNGSPRGVQAQLHCDLCAVSCTGADAYAAHIRGSKHQKVFKLHAKLGKPIPTLEPALATESPPGAEAK
  PTSPTGPSVCASSRPALAKRPVASKALCEGPPEPQAAGCRPQWGKPAQPKLEGPGAPTQGGSKEAPAGCSDAQPV
  GPEYVEEVFSDEGRVLRFHCKLCECSFNDLNAKDLHVRGRRHRLQYRKKVNPDLPIATEPSSRARKVLEERMRKQ
  RHLAEERLEQLRRWHAERRRLEEEPPQDVPPHAPPDWAQPLLMGRPESPASAPLQPGRRPASSDDRHVMCKHATI
  YPTEQELLAVQRAVSHAERALKLVSDTLAEEDRGRREEEGDKRSSVAPQTRVLKGVMRVGILAKGLLLRGDRNVR
  LALLCSEKPTHSLLRRIAQQLPRQLQMVTEDEYEVSSDPEANIVISSCEEPRMQVTISVTSPLMREDPSTDPGVE
  EPQADAGDVLSPKKCLESLAALRHARWFQARASGLQPCVIVIRVLRDLCRRVPTWGALPAWAMELLVEKAVSSAA
  GPLGPGDAVRRVLECVATGTLLTDGPGLQDPCERDQTDALEPMTLQEREDVTASAQHALRMLAFRQTHKVLGMDL
  LPPRHRLGARFRKRQRGPGEGEEGAGEKKRGRRGGEGLV

• Structural information:
  • Protein Domains: (570..93-)
    (/note="DZF-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU01040"-)
  • Interpro: IPR006561  IPR003604  IPR036236  IPR013087  
  • Prosite: PS51703
  • STRING: ENSP00000262961
• Other Databases: GeneCards:  ZFR2  Malacards:  ZFR2

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005634	nucleus	IBA	cellular component
GO:0003727	single-stranded RNA binding	IBA	molecular function
GO:0003725	double-stranded RNA binding	IBA	molecular function
GO:0008270	zinc ion binding	IEA	molecular function
GO:0003676	nucleic acid binding	IEA	molecular function

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200
Spermatogenic defects	MIK: 31037746
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq
31037746	Spermatogenic defects			28 men with azoospermia	Male infertility	Microarray