• Gene id: 23198

Gene Summary

• Gene Symbol: PSME4   Gene   UCSC   Ensembl
• Aliases: PA200
• Gene name: proteasome activator subunit 4
• Alternate names: proteasome activator complex subunit 4, proteasome (prosome, macropain) activator subunit 4, proteasome activator 200 kDa, proteasome activator PA200,
• Gene location: 2p16.2 (53970992: 53864068)     Exons: 49     NC_000012.12
• OMIM: 607705

KEGG pathways

Pathway id	Pathway name
hsa03050	Proteasome

Diseases

Associated diseases	References
Male factor infertility	MIK: 27003159
May contribute to occurrence and development of teratozoospermia	MIK: 26404029
Cryptorchidism	MIK: 28606200
Male infertility	MIK: 27003159
May contribute to occurrence and development of teratozoospermia	MIK: 26404029
Spermatogenic defects	MIK: 31037746
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
27003159	Male infertility				Male infertility
26404029	May contribute to occurrence and development of teratozoospermia, Male infertility				Male infertility
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq
31037746	Spermatogenic defects			28 men with azoospermia	Male infertility	Microarray