• Gene id: 23162

Gene Summary

• Gene Symbol: MAPK8IP3   Gene   UCSC   Ensembl
• Aliases: JIP-3, JIP3, JSAP1, NEDBA, SYD2, syd
• Gene name: mitogen-activated protein kinase 8 interacting protein 3
• Alternate names: C-Jun-amino-terminal kinase-interacting protein 3, C-jun-amino-terminal kinase interacting protein 3, JNK MAP kinase scaffold protein 3, JNK-interacting protein 3, JNK/SAPK-associated protein-1, JNK/stress-activated protein kinase-associated protein 1, homolog ,
• Gene location: 16p13.3 (1706182: 1770316)     Exons: 33     NC_000017.11
• Gene summary(Entrez): The protein encoded by this gene shares similarity with the product of Drosophila syd gene, required for the functional interaction of kinesin I with axonal cargo. Studies of the similar gene in mouse suggested that this protein may interact with, and reg
• OMIM: 605431

KEGG pathways

Pathway id	Pathway name
hsa04010	MAPK signaling pathway

Diseases

Associated diseases	References
May be important in spermatogenic cells during early postnatal development	MIK: 16595722
Male subfertility	MIK: 28681403
Cryptorchidism	MIK: 28606200
Male subfertility	MIK: 28681403
May be important in spermatogenic cells during early postnatal development	MIK: 16595722
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
16595722	May be important in spermatogenic cells during early postnatal development				Male infertility
28681403	Male subfertility	Methylation		78 (28 proven fertile males "controls," and 50 subfertile males "cases")	Male infertility	PRRC2A ANXA2 MAPK8IP3
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq