• Gene id: 23142

Gene Summary

• Gene Symbol: DCUN1D4   Gene   UCSC   Ensembl
• Gene name: defective in cullin neddylation 1 domain containing 4
• Alternate names: DCN1-like protein 4, DCN1, defective in cullin neddylation 1, domain containing 4, DCUN1 domain-containing protein 4, defective in cullin neddylation protein 1-like protein 4,
• Gene location: 4q12 (51842999: 51916836)     Exons: 20     NC_000004.12
• OMIM: 612977

Protein Summary

• Protein general information: Q92564  
  • Name: DCN1 like protein 4 (DCUN1 domain containing protein 4) (Defective in cullin neddylation protein 1 like protein 4)
  • Length: 292  
  • Mass: 34068
• Sequence:

  MHSDAAAVNFQLNSHLSTLANIHKIYHTLNKLNLTEDIGQDDHQTGSLRSCSSSDCFNKVMPPRKKRRPASGDDL
  SAKKSRHDSMYRKYDSTRIKTEEEAFSSKRCLEWFYEYAGTDDVVGPEGMEKFCEDIGVEPENVVMLVLAWKLDA
  QNMGYFTLQEWLKGMTSLQCDTTEKLRNTLDYLRSFLNDSTNFKLIYRYAFDFAREKDQRSLDINTAKCMLGLLL
  GKIWPLFPVFHQFLEQSKYKVINKDQWCNVLEFSRTINLDLSNYDEDGAWPVLLDEFVEWYKDKQMS

• Structural information:
  • Protein Domains: (101..28-)
    (/note="DCUN1-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00574"-)
  • Interpro: IPR014764  IPR042460  IPR005176  
  • Prosite: PS51229
  • PDB: 5V89
  • PDBsum: 5V89
  • STRING: ENSP00000389900
• Other Databases: GeneCards:  DCUN1D4  Malacards:  DCUN1D4

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0031624	ubiquitin conjugating enzyme binding	IBA	molecular function
GO:0097602	cullin family protein binding	IBA	molecular function
GO:0000151	ubiquitin ligase complex	IBA	cellular component
GO:0032182	ubiquitin-like protein binding	IBA	molecular function
GO:0045116	protein neddylation	IBA	biological process
GO:0051443	positive regulation of ubiquitin-protein transferase activity	IBA	biological process
GO:0005634	nucleus	IDA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0008150	biological_process	ND	biological process
GO:0003674	molecular_function	ND	molecular function

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881