|
Gene id |
23028 |
| Gene Summary KEGG pathways Diseases PubMed |
Gene Summary
|
|
Gene Symbol |
KDM1A Gene UCSC Ensembl |
|
Aliases |
AOF2, BHC110, CPRF, KDM1, LSD1 |
|
Gene name |
lysine demethylase 1A |
|
Alternate names |
lysine-specific histone demethylase 1A, BRAF35-HDAC complex protein BHC110, FAD-binding protein BRAF35-HDAC complex, 110 kDa subunit, amine oxidase (flavin containing) domain 2, flavin-containing amine oxidase domain-containing protein 2, lysine (K)-specific d, |
|
Gene location |
1p36.12 (23019442: 23083690) Exons: 21 NC_000016.10
|
|
Gene summary(Entrez) |
This gene encodes a nuclear protein containing a SWIRM domain, a FAD-binding motif, and an amine oxidase domain. This protein is a component of several histone deacetylase complexes, though it silences genes by functioning as a histone demethylase. Altern
|
|
OMIM |
609132 |
|
|
|
|
| Associated diseases |
References |
| Spermatogenesis defects | MIK: 29381885 |
| Aberrant CpGs in Low Motility Sperm | MIK: 21674046 |
| Important for Spermatogenesis | MIK: 29381885 |
| Male infertility | MIK: 29381885 |
| Teratozoospermia | MIK: 17327269 |
|
|
| PMID |
Condition |
Mutation |
Ethnicity |
Population details |
Infertility_type |
Associated_genes |
Abstract |
| 29381885 |
Important
for Sperma
togenesis,
Male infe
rtility
|
|
|
|
Male infertility |
|
Show abstract |
| 17327269 |
Teratozoos
permia
|
|
|
13 (5 controls,
8 cases)
|
Male infertility |
GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
|
Show abstract |
| 21674046 |
Aberrant C
pGs in Low
Motility
Sperm
|
|
|
18
|
Male infertility |
GSE26881
|
Show abstract |
|