• Gene id: 22828

Gene Summary

• Gene Symbol: SCAF8   Gene   UCSC   Ensembl
• Aliases: RBM16
• Gene name: SR-related CTD associated factor 8
• Alternate names: SR-related and CTD-associated factor 8, CDC5L complex-associated protein 7, RNA-binding motif protein 16, SR-like CTD-associated factor 8, protein SCAF8,
• Gene location: 6q25.2 (154733377: 154834243)     Exons: 22     NC_000006.12
• OMIM: 603972

Protein Summary

• Protein general information: Q9UPN6  
  • Name: SR related and CTD associated factor 8 (CDC5L complex associated protein 7) (RNA binding motif protein 16)
  • Length: 1271  
  • Mass: 140519
• Sequence:

  MEAVKTFNSELYSLNDYKPPISKAKMTQITKAAIKAIKFYKHVVQSVEKFIQKCKPEYKVPGLYVIDSIVRQSRH
  QFGQEKDVFAPRFSNNIISTFQNLYRCPGDDKSKIVRVLNLWQKNNVFKSEIIQPLLDMAAGIPPPVVTPVLAST
  TTAMSNTPGTPVTPVTPANVVQGLPDPWVSQITNTDTLAAVAQILQSPQGQQLQQLIQTLQIQQQKPQPSILQAL
  DAGLVVQLQALTAQLTAAAAAANTLTPLEQGVSFNKKLMDRFDFGEDSEHSEEPKKEIPASQLSHVSESVNNSIF
  HQIAEQLQQQNLEHLRQQLLEQQQPQKATPQDSQEGTFGSEHSASPSQGSSQQHFLEPEVNLDDSIDIQQQDMDI
  DEGQDGVEEEVFEQEAKKVAVRSRSRTHSRSRSRSPRKRRSRSRSGSRKRKHRKRSRSRSRERKRKSSRSYSSER
  RAREREKERQKKGLPPIRSKTLSVCSTTLWVGQVDKKATQQDLTNLFEEFGQIESINMIPPRGCAYVCMVHRQDA
  FRALQKLSSGSYKIGSKVIKIAWALNKGVKTEYKQFWDVDLGVTYIPWEKVKVDDLEGFAEGGMIDQETVNTEWE
  TVKSSEPVKETVQTTQSPTPVEKETVVTTQAEVFPPPVAMLQIPVAPAVPTVSLVPPAFPVSMPVPPPGFSPIPP
  PPFLRASFNPSQPPPGFMPPPVPPPVVPPPTIPPVVPTSLVQPSLSMTPETVKDVGFGSLVIPGGSVASNLATSA
  LPAGNVFNAPTKQAEPEEKVPHLIDHQISSGENTRSVIPNDISSNAAILGGQPPNVTSNSGILGVQRPNVSSNSE
  ILGVRPSNVSSSSGIIAAQPPNILNNSGILGIQPPSVSNSSGLLGVLPPNIPNNSGLVGVQPPNVPNTPGLLGTQ
  PPAGPQNLPPLSIPNQRMPTMPMLDIRPGLIPQAPGPRFPLIQPGIPPQRGIPPPSVLDSALHPPPRGPFPPGDI
  FSQPERPFLAPGRQSVDNVTNPEKRIPLGNDNIQQEGDRDYRFPPIETRESISRPPPVDVRDVVGRPIDPREGPG
  RPPLDGRDHFGRPPVDIRENLVRPGIDHLGRRDHFGFNPEKPWGHRGDFDEREHRVLPVYGGPKGLHEERGRFRS
  GNYRFDPRSGPWNRGFGQEVHRDFDDRRRPWERQRDRDDRDFDFCREMNGNRLGRDRIQNTWVPPPHARVFDYFE
  GATSQRKGDNVPQVNGENTERHAQPPPIPVQNDPELYEKLTSSNEINKEKSDTVADIESEPVVESTETEGT

• Structural information:
  • Protein Domains: (1..13-)
    (/note="CID-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00724-)
    (477..55-)
    (/note="RRM-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00176"-)
  • Interpro: IPR006569  IPR008942  IPR012677  IPR035979  IPR006903   IPR000504  IPR034370  
  • Prosite: PS51391 PS50102
  • CDD: cd12462
  • PDB: 2DIW 3D9I 3D9J 3D9K 3D9L 3D9M 3D9N 3D9O 3D9P
  • PDBsum: 2DIW 3D9I 3D9J 3D9K 3D9L 3D9M 3D9N 3D9O 3D9P
  • STRING: ENSP00000413098
• Other Databases: GeneCards:  SCAF8  Malacards:  SCAF8

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0000993	RNA polymerase II complex binding	IBA	molecular function
GO:0005737	cytoplasm	IBA	cellular component
GO:0006369	termination of RNA polymerase II transcription	IBA	biological process
GO:0006378	mRNA polyadenylation	IBA	biological process
GO:0003729	mRNA binding	IBA	molecular function
GO:0005849	mRNA cleavage factor complex	IBA	cellular component
GO:0032786	positive regulation of DNA-templated transcription, elongation	IDA	biological process
GO:0003723	RNA binding	IDA	molecular function
GO:2000805	negative regulation of termination of RNA polymerase II transcription, poly(A)-coupled	IDA	biological process
GO:1990269	RNA polymerase II C-terminal domain phosphoserine binding	IDA	molecular function
GO:0005634	nucleus	IDA	cellular component
GO:0043175	RNA polymerase core enzyme binding	IPI	molecular function
GO:0016363	nuclear matrix	ISS	cellular component
GO:0003676	nucleic acid binding	IEA	molecular function
GO:0005634	nucleus	IEA	cellular component
GO:0003723	RNA binding	IEA	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0016363	nuclear matrix	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0005654	nucleoplasm	IDA	cellular component

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)