• Gene id: 22826

Gene Summary

• Gene Symbol: DNAJC8   Gene   UCSC   Ensembl
• Aliases: HSPC331, SPF31
• Gene name: DnaJ heat shock protein family (Hsp40) member C8
• Alternate names: dnaJ homolog subfamily C member 8, DnaJ (Hsp40) homolog, subfamily C, member 8, splicing protein spf31,
• Gene location: 1p35.3 (28233028: 28200277)     Exons: 10     NC_000001.11

Protein Summary

• Protein general information: O75937  
  • Name: DnaJ homolog subfamily C member 8 (Splicing protein spf31)
  • Length: 253  
  • Mass: 29842
  • Tissue specificity: Ubiquitous. {ECO
• Sequence:

  MAASGESGTSGGGGSTEEAFMTFYSEVKQIEKRDSVLTSKNQIERLTRPGSSYFNLNPFEVLQIDPEVTDEEIKK
  RFRQLSILVHPDKNQDDADRAQKAFEAVDKAYKLLLDQEQKKRALDVIQAGKEYVEHTVKERKKQLKKEGKPTIV
  EEDDPELFKQAVYKQTMKLFAELEIKRKEREAKEMHERKRQREEEIEAQEKAKREREWQKNFEESRDGRVDSWRN
  FQANTKGKKEKKNRTFLRPPKVKMEQRE

• Structural information:
  • Protein Domains: (57..12-)
    (/note="J-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00286"-)
  • Interpro: IPR001623  IPR042858  IPR036869  
  • Prosite: PS50076
  • CDD: cd06257
  • STRING: ENSP00000263697
• Other Databases: GeneCards:  DNAJC8  Malacards:  DNAJC8

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005634	nucleus	IBA	cellular component
GO:0005634	nucleus	IDA	cellular component
GO:0030544	Hsp70 protein binding	IPI	molecular function
GO:0005634	nucleus	IEA	cellular component
GO:0000398	mRNA splicing, via spliceosome	TAS	biological process
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005634	nucleus	IEA	cellular component
GO:0045171	intercellular bridge	IDA	cellular component
GO:0005654	nucleoplasm	IDA	cellular component
GO:0005829	cytosol	IDA	cellular component

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)