• Gene id: 222698

Gene Summary

• Gene Symbol: NKAPL   Gene   UCSC   Ensembl
• Aliases: C6orf194, bA424I5.1
• Gene name: NFKB activating protein like
• Alternate names: NKAP-like protein,
• Gene location: 6p22.1 (28259296: 28260957)     Exons: 1     NC_000006.12
• OMIM: 602731

Protein Summary

• Protein general information: Q5M9Q1  
  • Name: NKAP like protein
  • Length: 402  
  • Mass: 46312
• Sequence:

  MPPVSRSSYSEDIVGSRRRRRSSSGSPPSPQSRCSSWDGCSRSHSRGREGLRPPWSELDVGALYPFSRSGSRGRL
  PRFRNYAFASSWSTSYSGYRYHRHCYAEERQSAEDYEKEESHRQRRLKERERIGELGAPEVWGPSPKFPQLDSDE
  HTPVEDEEEVTHQKSSSSDSNSEEHRKKKTSRSRNKKKRKNKSSKRKHRKYSDSDSNSESDTNSDSDDDKKRVKA
  KKKKKKKKHKTKKKKNKKTKKESSDSSCKDSEEDLSEATWMEQPNVADTMDLIGPEAPIIHTSQDEKPLKYGHAL
  LPGEGAAMAEYVKAGKRIPRRGEIGLTSEEIGSFECSGYVMSGSRHRRMEAVRLRKENQIYSADEKRALASFNQE
  ERRKRESKILASFREMVHKKTKEKDDK

• Structural information:
  • Interpro: IPR040466  IPR009269  
  • STRING: ENSP00000345716
• Other Databases: GeneCards:  NKAPL  Malacards:  NKAPL

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0003682	chromatin binding	IEA	molecular function
GO:0030154	cell differentiation	IEA	biological process
GO:0007283	spermatogenesis	IEA	biological process
GO:0005634	nucleus	IEA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005634	nucleus	IEA	cellular component

Diseases

Associated diseases	References
Spermatogenic defects	MIK: 31037746
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
31037746	Spermatogenic defects			16 (1 control, 15 cases)	Male infertility	GSE6023 analyzed using GEO2R