• Gene id: 221955

Gene Summary

• Gene Symbol: DAGLB   Gene   UCSC   Ensembl
• Aliases: DAGLBETA, KCCR13L
• Gene name: diacylglycerol lipase beta
• Alternate names: sn1-specific diacylglycerol lipase beta, DGL-beta,
• Gene location: 7p22.1 (6448011: 6409115)     Exons: 15     NC_000007.14
• OMIM: 612972

Protein Summary

• Protein general information: Q8NCG7  
  • Name: Sn1 specific diacylglycerol lipase beta (DGL beta) (EC 3.1.1. ) (KCCR13L)
  • Length: 672  
  • Mass: 73732
• Sequence:

  MPGMVLFGRRWAIASDDLVFPGFFELVVRVLWWIGILTLYLMHRGKLDCAGGALLSSYLIVLMILLAVVICTVSA
  IMCVSMRGTICNPGPRKSMSKLLYIRLALFFPEMVWASLGAAWVADGVQCDRTVVNGIIATVVVSWIIIAATVVS
  IIIVFDPLGGKMAPYSSAGPSHLDSHDSSQLLNGLKTAATSVWETRIKLLCCCIGKDDHTRVAFSSTAELFSTYF
  SDTDLVPSDIAAGLALLHQQQDNIRNNQEPAQVVCHAPGSSQEADLDAELENCHHYMQFAAAAYGWPLYIYRNPL
  TGLCRIGGDCCRSRTTDYDLVGGDQLNCHFGSILHTTGLQYRDFIHVSFHDKVYELPFLVALDHRKESVVVAVRG
  TMSLQDVLTDLSAESEVLDVECEVQDRLAHKGISQAARYVYQRLINDGILSQAFSIAPEYRLVIVGHSLGGGAAA
  LLATMLRAAYPQVRCYAFSPPRGLWSKALQEYSQSFIVSLVLGKDVIPRLSVTNLEDLKRRILRVVAHCNKPKYK
  ILLHGLWYELFGGNPNNLPTELDGGDQEVLTQPLLGEQSLLTRWSPAYSFSSDSPLDSSPKYPPLYPPGRIIHLQ
  EEGASGRFGCCSAAHYSAKWSHEAEFSKILIGPKMLTDHMPDILMRALDSVVSDRAACVSCPAQGVSSVDVA

• Structural information:
  • Interpro: IPR029058  IPR002921  
  • Prosite: PS00120
  • STRING: ENSP00000297056
• Other Databases: GeneCards:  DAGLB  Malacards:  DAGLB

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0042136	neurotransmitter biosynthetic process	IBA	biological process
GO:0022008	neurogenesis	IBA	biological process
GO:0098921	retrograde trans-synaptic signaling by endocannabinoid	IBA	biological process
GO:0071926	endocannabinoid signaling pathway	IBA	biological process
GO:0046340	diacylglycerol catabolic process	IBA	biological process
GO:0045211	postsynaptic membrane	IBA	cellular component
GO:0019369	arachidonic acid metabolic process	IBA	biological process
GO:0007216	G protein-coupled glutamate receptor signaling pathway	IBA	biological process
GO:0016298	lipase activity	IDA	molecular function
GO:0019369	arachidonic acid metabolic process	IDA	biological process
GO:0005886	plasma membrane	IDA	cellular component
GO:0050727	regulation of inflammatory response	ISS	biological process
GO:0001516	prostaglandin biosynthetic process	ISS	biological process
GO:0010898	positive regulation of triglyceride catabolic process	ISS	biological process
GO:0004806	triglyceride lipase activity	ISS	molecular function
GO:0006629	lipid metabolic process	IEA	biological process
GO:0046872	metal ion binding	IEA	molecular function
GO:0016787	hydrolase activity	IEA	molecular function
GO:0005886	plasma membrane	IEA	cellular component
GO:0016042	lipid catabolic process	IEA	biological process
GO:0006629	lipid metabolic process	IEA	biological process
GO:0016020	membrane	IEA	cellular component
GO:0016021	integral component of membrane	IEA	cellular component
GO:0004806	triglyceride lipase activity	IEA	molecular function
GO:0005886	plasma membrane	TAS	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0007405	neuroblast proliferation	IEA	biological process
GO:0022008	neurogenesis	IEA	biological process
GO:0042136	neurotransmitter biosynthetic process	IEA	biological process
GO:0019369	arachidonic acid metabolic process	IEA	biological process
GO:0005886	plasma membrane	IEA	cellular component
GO:0005654	nucleoplasm	IDA	cellular component
GO:0005886	plasma membrane	IDA	cellular component
GO:0005765	lysosomal membrane	HDA	cellular component

KEGG pathways

Pathway id	Pathway name
hsa04723	Retrograde endocannabinoid signaling
hsa04925	Aldosterone synthesis and secretion

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Cryptorchidism	MIK: 28606200

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq