• Gene id: 220032

Gene Summary

• Gene Symbol: GDPD4   Gene   UCSC   Ensembl
• Aliases: GDE6
• Gene name: glycerophosphodiester phosphodiesterase domain containing 4
• Alternate names: glycerophosphodiester phosphodiesterase domain-containing protein 4, GDPD domain containing protein, glycerophosphodiester phosphodiesterase 6, ugpQ,
• Gene location: 11q13.5 (77301698: 77216557)     Exons: 20     NC_000011.10

Protein Summary

• Protein general information: Q6W3E5  
  • Name: Glycerophosphodiester phosphodiesterase domain containing protein 4 (EC 3.1. . ) (Glycerophosphodiester phosphodiesterase 6) (UgpQ)
  • Length: 623  
  • Mass: 71996
• Sequence:

  MLLFLWIETSSEYFNFDWVTFLGTGYWFFWSIFILSLARILTAYSSLLLLLGFLLLWERIELYLHLCHKILILLV
  ILLCVILMFIICKFWKERWLVAGLSMQIFAPYVHLVSITVMVILFWPVAFYVACLEREVRMRRYRMTHSEKKRLK
  QCNVITRLRGLQVPVGLPFLLILLGLYLMPLGIYSPCIQEKENLGPKPTIFGHRGAPMLGPENTMMSFEKAVEHG
  AHGLETDIHLSYDHVPFLMHDFDLKRTTNIGEVQPESACENPAFFNWDFLSTLNAGKWFVKPELRPFYNMKPLSE
  ADKERARNQSIPTLADLLTLAEKERKFVIFDLHRPPPKHPLRHTFVRQVVSVILASKIEQHLIFWLPAHDRQYVR
  SVAPGFQHVGRLVSIETLAKNNISIINVDYKKLFPNGLRDYKAANIHINVYTVNEPWLFSLAWCSRINSVTTDNI
  GLLSQLDHPHFFMTPKFYVFMWLLADIISVLFIVAIFCFHWRRETEKEKLFETSSTRTDTQSGNLHIAMKPPVRV
  VEGPWTLAALYPALPKSGKEHQGHFNFAAPSKKLLPIKNAVTPLKPGKHEIQPPMPTVVFELTQAPTRQATSEAT
  FQTTLPTLKVDKPTMPSIEVPYP

• Structural information:
  • Protein Domains: (198..45-)
    (/note="GP-PDE"-)
  • Interpro: IPR030395  IPR017946  
  • Prosite: PS51704
  • STRING: ENSP00000320815
• Other Databases: GeneCards:  GDPD4  Malacards:  GDPD4

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0006629	lipid metabolic process	IEA	biological process
GO:0008081	phosphoric diester hydrolase activity	IEA	molecular function
GO:0046872	metal ion binding	IEA	molecular function
GO:0016787	hydrolase activity	IEA	molecular function
GO:0016021	integral component of membrane	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0016020	membrane	IEA	cellular component

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq