• Gene id: 199920

Gene Summary

• Gene Symbol: FYB2   Gene   UCSC   Ensembl
• Aliases: ARAP, C1orf168
• Gene name: FYN binding protein 2
• Alternate names: FYN-binding protein 2, RP4-758N20.2, activation-dependent, raft-recruited ADAP-like phosphoprotein, uncharacterized protein C1orf168,
• Gene location: 1p32.2 (56831985: 56718788)     Exons: 27     NC_000001.11
• OMIM: 618478

Protein Summary

• Protein general information: Q5VWT5  
  • Name: FYN binding protein 2 (Activation dependent, raft recruited ADAP like phosphoprotein)
  • Length: 728  
  • Mass: 82070
  • Tissue specificity: Expressed in T-cells (at protein level). Widely expressed. {ECO
• Sequence:

  MEGEGVRNFKELRAKFQNLDAPPLPGPIKFPAGVSPKGDIGGTQSTQILANGKPLSSNHKQRTPYCSSSESQPLQ
  PQKIKLAQKSEIPKCSNSPGPLGKSTVCSATSSQKASLLLEVTQSNVEIITKEKVMVANSFRNKLWNWEKVSSQK
  SEMSSALLLANYGSKAIHLEGQKGMGLTPEEPRKKLETKGAQTLPSQKHVVAPKILHNVSEDPSFVISQHIRKSW
  ENPPPERSPASSPCQPIYECELASQAPEKQPDVRHHHLPKTKPLPSIDSLGPPPPKPSRPPIVNLQAFQRQPAAV
  PKTQGEVTVEEGSLSPERLFNAEFEEPHNYEATISYLRHSGNSINLCTAKEIADPTYEVGIEELQKPGKNFPYPE
  PSAKHEDKKMKEKQPCELKPKNTEKEPYSNHVFKVDACEGTPEKIQMTNVHTGRRNMLAGKQEAMIDIIQTNPCP
  EGPKLARHSQGHCGHLEVLESTKETPDLGVSKTSSISEEIYDDVEYSRKEVPKLNYSSSLASSSEENRELYEDVY
  KTKNNYPKIDLDGKEALKRLQQFFKKEKDRFKIKKTKSKENLSAFSILLPDLELKSQEVIIYDDVDLSEKESKDE
  DKLKMWKPKFLTPKEKKEKNGAEESESFSPRNFFKTKKQNLEKNRMKREEKLFRERFKYDKEIIVINTAVACSNN
  SRNGIFDLPISPGEELEVIDTTEQNLVICRNSKGKYGYVLIEHLDFKHQSWSP

• Structural information:
  • Protein Domains: (664..72-)
    (/note="SH3-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00192"-)
  • Interpro: IPR029294  IPR036028  IPR001452  
  • Prosite: PS50002
  • STRING: ENSP00000345972
• Other Databases: GeneCards:  FYB2  Malacards:  FYB2

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0007229	integrin-mediated signaling pathway	IEA	biological process
GO:0005886	plasma membrane	IEA	cellular component
GO:0072659	protein localization to plasma membrane	IBA	biological process
GO:0007229	integrin-mediated signaling pathway	IBA	biological process
GO:0050852	T cell receptor signaling pathway	IBA	biological process
GO:0005886	plasma membrane	IBA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0045121	membrane raft	IEA	cellular component
GO:0001772	immunological synapse	IDA	cellular component
GO:0045121	membrane raft	IDA	cellular component
GO:0033627	cell adhesion mediated by integrin	IMP	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0050852	T cell receptor signaling pathway	IMP	biological process

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)