• Gene id: 197258

Gene Summary

• Gene Symbol: FCSK   Gene   UCSC   Ensembl
• Aliases: 1110046B12Rik, CDGF2, FUK
• Gene name: fucose kinase
• Alternate names: L-fucose kinase, fucokinase,
• Gene location: 16q22.1 (70454589: 70480273)     Exons: 27     NC_000016.10
• Gene summary(Entrez): The protein encoded by this gene belongs to the GHMP (galacto-, homoserine, mevalonate and phosphomevalonate) kinase family and catalyzes the phosphorylation of L-fucose to form beta-L-fucose 1-phosphate. This enzyme catalyzes the first step in the utiliz
• OMIM: 608675

Protein Summary

• Protein general information: Q8N0W3  
  • Name: L fucose kinase (Fucokinase) (EC 2.7.1.52)
  • Length: 1084  
  • Mass: 117623
  • Tissue specificity: Expressed in fibroblasts. {ECO
• Sequence:

  MEQPKGVDWTVIILTCQYKDSVQVFQRELEVRQKREQIPAGTLLLAVEDPEKRVGSGGATLNALLVAAEHLSARA
  GFTVVTSDVLHSAWILILHMGRDFPFDDCGRAFTCLPVENPEAPVEALVCNLDCLLDIMTYRLGPGSPPGVWVCS
  TDMLLSVPANPGISWDSFRGARVIALPGSPAYAQNHGVYLTDPQGLVLDIYYQGTEAEIQRCVRPDGRVPLVSGV
  VFFSVETAERLLATHVSPPLDACTYLGLDSGARPVQLSLFFDILHCMAENVTREDFLVGRPPELGQGDADVAGYL
  QSARAQLWRELRDQPLTMAYVSSGSYSYMTSSASEFLLSLTLPGAPGAQIVHSQVEEQQLLAAGSSVVSCLLEGP
  VQLGPGSVLQHCHLQGPIHIGAGCLVTGLDTAHSKALHGRELRDLVLQGHHTRLHGSPGHAFTLVGRLDSWERQG
  AGTYLNVPWSEFFKRTGVRAWDLWDPETLPAEYCLPSARLFPVLHPSRELGPQDLLWMLDHQEDGGEALRAWRAS
  WRLSWEQLQPCLDRAATLASRRDLFFRQALHKARHVLEARQDLSLRPLIWAAVREGCPGPLLATLDQVAAGAGDP
  GVAARALACVADVLGCMAEGRGGLRSGPAANPEWMRPFSYLECGDLAAGVEALAQERDKWLSRPALLVRAARHYE
  GAGQILIRQAVMSAQHFVSTEQVELPGPGQWVVAECPARVDFSGGWSDTPPLAYELGGAVLGLAVRVDGRRPIGA
  RARRIPEPELWLAVGPRQDEMTVKIVCRCLADLRDYCQPHAPGALLKAAFICAGIVHVHSELQLSEQLLRTFGGG
  FELHTWSELPHGSGLGTSSILAGTALAALQRAAGRVVGTEALIHAVLHLEQVLTTGGGWQDQVGGLMPGIKVGRS
  RAQLPLKVEVEEVTVPEGFVQKLNDHLLLVYTGKTRLARNLLQDVLRSWYARLPAVVQNAHSLVRQTEECAEGFR
  QGSLPLLGQCLTSYWEQKKLMAPGCEPLTVRRMMDVLAPHVHGQSLAGAGGGGFLYLLTKEPQQKEALEAVLAKT
  EGLGNYSIHLVEVDTQGLSLKLLGTEASTCCPFP

• Structural information:
  • Interpro: IPR012887  IPR013750  IPR036554  IPR006204  IPR020568  
  • STRING: ENSP00000288078
• Other Databases: GeneCards:  FCSK  Malacards:  FCSK

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0042352	GDP-L-fucose salvage	IBA	biological process
GO:0050201	fucokinase activity	IBA	molecular function
GO:0050201	fucokinase activity	IMP	molecular function
GO:0042352	GDP-L-fucose salvage	IMP	biological process
GO:0016772	transferase activity, transferring phosphorus-containing groups	IEA	molecular function
GO:0005524	ATP binding	IEA	molecular function
GO:0016301	kinase activity	IEA	molecular function
GO:0016740	transferase activity	IEA	molecular function
GO:0016310	phosphorylation	IEA	biological process
GO:0000166	nucleotide binding	IEA	molecular function
GO:0005524	ATP binding	IEA	molecular function
GO:0050201	fucokinase activity	IEA	molecular function
GO:0050201	fucokinase activity	TAS	molecular function
GO:0005829	cytosol	TAS	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:1903350	response to dopamine	IEA	biological process
GO:0050201	fucokinase activity	IEA	molecular function
GO:0046835	carbohydrate phosphorylation	IEA	biological process
GO:0050201	fucokinase activity	NAS	molecular function

KEGG pathways

Pathway id	Pathway name
hsa01100	Metabolic pathways
hsa00520	Amino sugar and nucleotide sugar metabolism
hsa00051	Fructose and mannose metabolism

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881