• Gene id: 196743

Gene Summary

• Gene Symbol: PAOX   Gene   UCSC   Ensembl
• Aliases: PAO
• Gene name: polyamine oxidase
• Alternate names: peroxisomal N(1)-acetyl-spermine/spermidine oxidase, peroxisomal N1-acetyl-spermine/spermidine oxidase, polyamine oxidase (exo-N4-amino),
• Gene location: 10q26.3 (133379261: 133391693)     Exons: 8     NC_000010.11
• OMIM: 615853

Protein Summary

• Protein general information: Q6QHF9  
  • Name: Peroxisomal N(1) acetyl spermine/spermidine oxidase (EC 1.5.3.13) (Polyamine oxidase)
  • Length: 511  
  • Mass: 55513
  • Tissue specificity: Widely expressed. Not detected in spleen. Expressed at lower level in neoplastic tissues. {ECO
• Sequence:

  MESTGSVGEAPGGPRVLVVGGGIAGLGAAQRLCGHSAFPHLRVLEATARAGGRIRSERCFGGVVEVGAHWIHGPS
  RGNPVFQLAAEYGLLGEKELSQENQLVETGGHVGLPSVSYASSGASVSLQLVAEMATLFYGLIDQTREFLHAAET
  PVPSVGEYLKKEIGQHVAGWTEDEETRKLKLAVLNSFFNLECCVSGTHSMDLVALAPFGEYTVLPGLDCTFSKGY
  QGLTNCMMAALPEDTVVFEKPVKTIHWNGSFQEAAFPGETFPVSVECEDGDRFPAHHVIVTVPLGFLREHLDTFF
  DPPLPAEKAEAIRKIGFGTNNKIFLEFEEPFWEPDCQLIQLVWEDTSPLEDAAPELQDAWFRKLIGFVVLPAFAS
  VHVLCGFIAGLESEFMETLSDEEVLLCLTQVLRRVTGNPRLPAPKSVLRSRWHSAPYTRGSYSYVAVGSTGGDLD
  LLAQPLPADGAGAQLQILFAGEATHRTFYSTTHGALLSGWREADRLLSLWAPQVQQPRPRL

• Structural information:
  • Interpro: IPR002937  IPR036188  
  • STRING: ENSP00000278060
• Other Databases: GeneCards:  PAOX  Malacards:  PAOX

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0046592	polyamine oxidase activity	IBA	molecular function
GO:0016491	oxidoreductase activity	IBA	molecular function
GO:0055114	oxidation-reduction process	IEA	biological process
GO:0016491	oxidoreductase activity	IEA	molecular function
GO:0055114	oxidation-reduction process	IEA	biological process
GO:0016491	oxidoreductase activity	IEA	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0005777	peroxisome	IEA	cellular component
GO:0052899	N(1),N(12)-diacetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity	IEA	molecular function
GO:0052904	N1-acetylspermidine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity	IEA	molecular function
GO:0052902	spermidine:oxygen oxidoreductase (3-aminopropanal-forming) activity	IEA	molecular function
GO:0052903	N1-acetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity	IEA	molecular function
GO:0052901	spermine:oxygen oxidoreductase (spermidine-forming) activity	IEA	molecular function
GO:0005782	peroxisomal matrix	TAS	cellular component
GO:0005782	peroxisomal matrix	TAS	cellular component
GO:0005782	peroxisomal matrix	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0006596	polyamine biosynthetic process	TAS	biological process
GO:0006625	protein targeting to peroxisome	TAS	biological process
GO:0005777	peroxisome	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0008215	spermine metabolic process	IEA	biological process
GO:0009446	putrescine biosynthetic process	IDA	biological process
GO:0046208	spermine catabolic process	IDA	biological process
GO:1901307	positive regulation of spermidine biosynthetic process	IDA	biological process
GO:0046592	polyamine oxidase activity	IDA	molecular function
GO:0046203	spermidine catabolic process	IDA	biological process
GO:0009447	putrescine catabolic process	IDA	biological process

KEGG pathways

Pathway id	Pathway name
hsa04146	Peroxisome

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200
Hypospermatogenesis	MIK: 28361989
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq
28361989	Hypospermatogenesis			6 (3 controls, 3 Klienfelter syndrome	Male infertility	Microarray