• Gene id: 196074

Gene Summary

• Gene Symbol: METTL15   Gene   UCSC   Ensembl
• Aliases: METT5D1
• Gene name: methyltransferase like 15
• Alternate names: 12S rRNA N4-methylcytidine (m4C) methyltransferase, probable methyltransferase-like protein 15, 12S rRNA m4C methyltransferase, methyltransferase 5 domain containing 1, methyltransferase 5 domain-containing protein 1, methyltransferase-like protein 15, probable,
• Gene location: 11p14.1 (28108250: 28527040)     Exons: 19     NC_000011.10
• OMIM: 618711

Protein Summary

• Protein general information: A6NJ78  
  • Name: 12S rRNA N4 methylcytidine (m4C) methyltransferase (12S rRNA m4C methyltransferase) (EC 2.1.1. ) (Methyltransferase 5 domain containing protein 1) (Methyltransferase like protein 15)
  • Length: 407  
  • Mass: 46121
• Sequence:

  MLRYPYFCRMYKECLSCWLESGIPNLGVWPNRIHTTAEKYREYEAREQTDQTQAQELHRSQDRDFETMAKLHIPV
  MVDEVVHCLSPQKGQIFLDMTFGSGGHTKAILQKESDIVLYALDRDPTAYALAEHLSELYPKQIRAMLGQFSQAE
  ALLMKAGVQPGTFDGVLMDLGCSSMQLDTPERGFSLRKDGPLDMRMDGGRYPDMPTAADVVNALDQQALASILRT
  YGEEKHAKKIASAIVQARSIYPITRTQQLASIVAGAFPPSAIYTRKDLLQRSTHIATKTFQALRIFVNNELNELY
  TGLKTAQKFLRPGGRLVALSFHSLEDRIVKRFLLGISMTERFNLSVRQQVMKTSQLGSDHENTEEVSMRRAPLMW
  ELIHKKVLSPQDQDVQDNPRGRSAKLRAAIKL

• Structural information:
  • Interpro: IPR002903  IPR023397  IPR029063  
  • STRING: ENSP00000384369
• Other Databases: GeneCards:  METTL15  Malacards:  METTL15

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0071424	rRNA (cytosine-N4-)-methyltransferase activity	IBA	molecular function
GO:0070475	rRNA base methylation	IBA	biological process
GO:0008168	methyltransferase activity	IEA	molecular function
GO:0032259	methylation	IEA	biological process
GO:0016740	transferase activity	IEA	molecular function
GO:0005739	mitochondrion	IEA	cellular component
GO:0008168	methyltransferase activity	IEA	molecular function
GO:0005759	mitochondrial matrix	IEA	cellular component

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)