• Gene id: 1955

Gene Summary

• Gene Symbol: MEGF9   Gene   UCSC   Ensembl
• Aliases: EGFL5
• Gene name: multiple EGF like domains 9
• Alternate names: multiple epidermal growth factor-like domains protein 9, EGF-like-domain, multiple 5, epidermal growth factor-like protein 5,
• Gene location: 9q33.2 (120714469: 120600810)     Exons: 13     NC_000009.12
• OMIM: 604268

Protein Summary

• Protein general information: Q9H1U4  
  • Name: Multiple epidermal growth factor like domains protein 9 (Multiple EGF like domains protein 9) (Epidermal growth factor like protein 5) (EGF like protein 5)
  • Length: 602  
  • Mass: 62984
• Sequence:

  MNGGAERAMRSLPSLGGLALLCCAAAAAAAAVASAASAGNVTGGGGAAGQVDASPGPGLRGEPSHPFPRATAPTA
  QAPRTGPPRATVHRPLAATSPAQSPETTPLWATAGPSSTTFQAPLGPSPTTPPAAERTSTTSQAPTRPAPTTLST
  TTGPAPTTPVATTVPAPTTPRTPTPDLPSSSNSSVLPTPPATEAPSSPPPEYVCNCSVVGSLNVNRCNQTTGQCE
  CRPGYQGLHCETCKEGFYLNYTSGLCQPCDCSPHGALSIPCNSSGKCQCKVGVIGSICDRCQDGYYGFSKNGCLP
  CQCNNRSASCDALTGACLNCQENSKGNHCEECKEGFYQSPDATKECLRCPCSAVTSTGSCSIKSSELEPECDQCK
  DGYIGPNCNKCENGYYNFDSICRKCQCHGHVDPVKTPKICKPESGECINCLHNTTGFWCENCLEGYVHDLEGNCI
  KKEVILPTPEGSTILVSNASLTTSVPTPVINSTFTPTTLQTIFSVSTSENSTSALADVSWTQFNIIILTVIIIVV
  VLLMGFVGAVYMYREYQNRKLNAPFWTIELKEDNISFSSYHDSIPNADVSGLLEDDGNEVAPNGQLTLTTPIHNY
  KA

• Structural information:
  • Protein Domains: (204..25-)
    1 (/note="Laminin-EGF-like)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00460-)
    (254..30-)
    2 (/note="Laminin-EGF-like)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00460-)
    (301..34-)
    3 (/note="Laminin-EGF-like)
    (/evidence="ECO-)
  • Interpro: IPR013032  IPR000742  IPR002049  
  • Prosite: PS00022 PS01186 PS01248 PS50027
  • STRING: ENSP00000363040
• Other Databases: GeneCards:  MEGF9  Malacards:  MEGF9

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0009888	tissue development	IBA	biological process
GO:0034446	substrate adhesion-dependent cell spreading	IBA	biological process
GO:0005201	extracellular matrix structural constituent	IBA	molecular function
GO:0009887	animal organ morphogenesis	IBA	biological process
GO:0016477	cell migration	IBA	biological process
GO:0043256	laminin complex	IBA	cellular component
GO:0070831	basement membrane assembly	IBA	biological process
GO:0016021	integral component of membrane	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0005604	basement membrane	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0008150	biological_process	ND	biological process
GO:0005575	cellular_component	ND	cellular component

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)