• Gene id: 1796

Gene Summary

• Gene Symbol: DOK1   Gene   UCSC   Ensembl
• Aliases: P62DOK, pp62
• Gene name: docking protein 1
• Alternate names: docking protein 1, Downstream of tyrosine kinase 1,
• Gene location: 2p13.1 (74549019: 74557550)     Exons: 6     NC_000002.12
• Gene summary(Entrez): The protein encoded by this gene is part of a signal transduction pathway downstream of receptor tyrosine kinases. The encoded protein is a scaffold protein that helps form a platform for the assembly of multiprotein signaling complexes. Several transcrip
• OMIM: 602510

Protein Summary

• Protein general information: Q99704  
  • Name: Docking protein 1 (Downstream of tyrosine kinase 1) (p62(dok)) (pp62)
  • Length: 481  
  • Mass: 52392
  • Tissue specificity: Expressed in pancreas, heart, leukocyte and spleen. Expressed in both resting and activated peripheral blood T-cells. Expressed in breast cancer. {ECO
• Sequence:

  MDGAVMEGPLFLQSQRFGTKRWRKTWAVLYPASPHGVARLEFFDHKGSSSGGGRGSSRRLDCKVIRLAECVSVAP
  VTVETPPEPGATAFRLDTAQRSHLLAADAPSSAAWVQTLCRNAFPKGSWTLAPTDNPPKLSALEMLENSLYSPTW
  EGSQFWVTVQRTEAAERCGLHGSYVLRVEAERLTLLTVGAQSQILEPLLSWPYTLLRRYGRDKVMFSFEAGRRCP
  SGPGTFTFQTAQGNDIFQAVETAIHRQKAQGKAGQGHDVLRADSHEGEVAEGKLPSPPGPQELLDSPPALYAEPL
  DSLRIAPCPSQDSLYSDPLDSTSAQAGEGVQRKKPLYWDLYEHAQQQLLKAKLTDPKEDPIYDEPEGLAPVPPQG
  LYDLPREPKDAWWCQARVKEEGYELPYNPATDDYAVPPPRSTKPLLAPKPQGPAFPEPGTATGSGIKSHNSALYS
  QVQKSGASGSWDCGLSRVGTDKTGVKSEGST

• Structural information:
  • Protein Domains: (4..11-)
    (/note="PH-)
    (151..25-)
    (/note="IRS-type-PTB)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00389"-)
  • Interpro: IPR037751  IPR002404  IPR011993  IPR001849  
  • Prosite: PS51064
  • CDD: cd01203
  • PDB: 2V76
  • PDBsum: 2V76
  • STRING: ENSP00000233668
• Other Databases: GeneCards:  DOK1  Malacards:  DOK1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005634	nucleus	IDA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005634	nucleus	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0007166	cell surface receptor signaling pathway	TAS	biological process
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	TAS	biological process
GO:0007165	signal transduction	TAS	biological process
GO:0007165	signal transduction	TAS	biological process
GO:0007411	axon guidance	TAS	biological process
GO:0045742	positive regulation of epidermal growth factor receptor signaling pathway	TAS	biological process
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0007265	Ras protein signal transduction	IEA	biological process
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	IEA	biological process
GO:0035556	intracellular signal transduction	IEA	biological process
GO:0038145	macrophage colony-stimulating factor signaling pathway	IEA	biological process
GO:0005634	nucleus	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0048471	perinuclear region of cytoplasm	IEA	cellular component
GO:0005829	cytosol	IDA	cellular component

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881