• Gene id: 1655

Gene Summary

• Gene Symbol: DDX5   Gene   UCSC   Ensembl
• Aliases: G17P1, HLR1, HUMP68, p68
• Gene name: DEAD-box helicase 5
• Alternate names: probable ATP-dependent RNA helicase DDX5, ATP-dependent RNA helicase DDX5, DEAD (Asp-Glu-Ala-Asp) box helicase 5, DEAD (Asp-Glu-Ala-Asp) box polypeptide 5, DEAD box protein 5, DEAD box-5, DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 5 (RNA helicase, 68kD), RNA ,
• Gene location: 17q23.3 (64506865: 64498253)     Exons: 16     NC_000017.11
• Gene summary(Entrez): This gene encodes a member of the DEAD box family of RNA helicases that are involved in a variety of cellular processes as a result of its role as an adaptor molecule, promoting interactions with a large number of other factors. This protein is involved i
• OMIM: 180630

KEGG pathways

Pathway id	Pathway name
hsa05202	Transcriptional misregulation in cancer
hsa05205	Proteoglycans in cancer
hsa03040	Spliceosome

Diseases

Associated diseases	References
Chronic renal failure	GAD: 21085059
Spermatogenesis defects	MIK: 31123254
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Important for Spermatogenesis	MIK: 31123254
Male infertility	MIK: 31123254
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
31123254	Important for Spermatogenesis, Male infertility	Knockout mouse model			Male infertility	PLZF
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881