• Gene id: 164395

Gene Summary

• Gene Symbol: TTLL9   Gene   UCSC   Ensembl
• Aliases: C20orf125
• Gene name: tubulin tyrosine ligase like 9
• Alternate names: probable tubulin polyglutamylase TTLL9, tubulin tyrosine ligase-like family, member 9, tubulin--tyrosine ligase-like protein 9,
• Gene location: 20q11.21 (31870633: 31944958)     Exons: 22     NC_000020.11
• OMIM: 0

Protein Summary

• Protein general information: Q3SXZ7  
  • Name: Probable tubulin polyglutamylase TTLL9 (EC 6. . . ) (Tubulin tyrosine ligase like protein 9)
  • Length: 439  
  • Mass: 51472
• Sequence:

  MVPSREALLGPGTTAIRCPKKLQNQNYKGHGLSKGKEREQRASIRFKTTLMNTLMDVLRHRPGWVEVKDEGEWDF
  YWCDVSWLRENFDHTYMDEHVRISHFRNHYELTRKNYMVKNLKRFRKQLEREAGKLEAAKCDFFPKTFEMPCEYH
  LFVEEFRKNPGITWIMKPVARSQGKGIFLFRRLKDIVDWRKDTRSSDDQKDDIPVENYVAQRYIENPYLIGGRKF
  DLRVYVLVMSVFAECLLWSGHRRQDVHLTNVAVQKTSPDYHPKKGCKWTLQRFRQYLASKHGPEAVETLFRDIDN
  IFVKSLQSVQKVIISDKHCFELYGYDILIDQDLKPWLLEVNASPSLTASSQEDYELKTCLLEDTLHVVDMEARLT
  GREKRVGGFDLMWNDGPVSREEGAPDLSGMGNFVTNTHLGCVNDRKKQLRQLFCSLQVQKKASS

• Structural information:
  • Protein Domains: (40..38-)
    (/note="TTL-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00568"-)
  • Interpro: IPR013815  IPR004344  IPR027751  
  • Prosite: PS51221
  • STRING: ENSP00000442515
• Other Databases: GeneCards:  TTLL9  Malacards:  TTLL9

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0015631	tubulin binding	IBA	molecular function
GO:0018095	protein polyglutamylation	IBA	biological process
GO:0070740	tubulin-glutamic acid ligase activity	IBA	molecular function
GO:0000226	microtubule cytoskeleton organization	IBA	biological process
GO:0005929	cilium	IBA	cellular component
GO:0006464	cellular protein modification process	IEA	biological process
GO:0005524	ATP binding	IEA	molecular function
GO:0042995	cell projection	IEA	cellular component
GO:0000166	nucleotide binding	IEA	molecular function
GO:0005874	microtubule	IEA	cellular component
GO:0005524	ATP binding	IEA	molecular function
GO:0005929	cilium	IEA	cellular component
GO:0005856	cytoskeleton	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0016874	ligase activity	IEA	molecular function
GO:0036064	ciliary basal body	IEA	cellular component
GO:0018095	protein polyglutamylation	IEA	biological process
GO:0030317	flagellated sperm motility	IEA	biological process
GO:0005856	cytoskeleton	IEA	cellular component

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)