• Gene id: 163782

Gene Summary

• Gene Symbol: KANK4   Gene   UCSC   Ensembl
• Aliases: ANKRD38, dJ1078M7.1
• Gene name: KN motif and ankyrin repeat domains 4
• Alternate names: KN motif and ankyrin repeat domain-containing protein 4, ankyrin repeat domain 38, ankyrin repeat domain-containing protein 38, kidney ankyrin repeat-containing protein 4,
• Gene location: 1p31.3 (62319433: 62236164)     Exons: 12     NC_000001.11
• OMIM: 614612

Protein Summary

• Protein general information: Q5T7N3  
  • Name: KN motif and ankyrin repeat domain containing protein 4 (Ankyrin repeat domain containing protein 38)
  • Length: 995  
  • Mass: 107342
  • Tissue specificity: Strongly expressed in colon, liver, lung, skeletal muscle and kidney. {ECO
• Sequence:

  MEKTDAKDQSSQGDEEKDPPKSHPYSVETPYGFHLDLDFLKYVDDIEKGNTIKRIPIHRRAKQAKFSTLPRNFSL
  PDSGARPPAAPPLQNWSPVVPREASLGTQEQNQSPPLGNAPQASTSRSEVSYHRKALLAEATRQLEAAEPEDAEL
  TFGSGRPQLLRASSMPATLLHSRASEEPGLSLGPPAPPALPPLQGEGSVCDGTFEPAEGLAGFHSSSPRASTRIP
  ELVQEGAEPPEGVVKVPNHLPLPGPPFSFQNVLVVLEDKEDEHNAREAEVLFTPGSPTPSPPPLPSPIPENELLL
  EEIELNISEIPPPPPVEVDMRSIGIRVTEESLGLARVDPGSISSLKQQVSALEGELSGRTEELAQVRTALQQQEE
  EIKAREQRIRELEFTVAQLEGQFHQENAKDTQGQTDVMVNTDPVHGLLTRESCDKGIEVNLLGSMESESWGHRGE
  ENGLLWGPDGHKQGNQSPAERVLLPQLSLPQGPEQVLTSSVHSFLSTELRIEEAGTEQEGGPQGGTRGAGGFLWG
  SDRKTPPAGREETSSNLPGKEHPGRPPSSPTDATIGQYVKKIQELLQEQWNCLEHGYPELASAIKQPASKLSSIQ
  SQLLSSLNLLLSAYSAQAHPPKEPPASSSSPPVEISPSTSLKSIMKKKDYGFRAGGNGTKKNLQFVGVNGGYETT
  SSEETSGEDSTPEDLSDSEAEKKCDGPDHKHVKDAHLTCEAGQGIPEGTCHAAQESGPGEEVPHSKAERYKPSEE
  FLNACRALSQHLPETGTTTDQLLRQSLNTISQEWFRVSSRKSSSPAVVASYLHEVQPHSPHFLKLLVNLADHNGN
  TALHYSVSHSNFSIVKLLLETGVCNVDHQNKAGYTAVMITPLASAETNEDMAVVWKLLREGNVNIQATQGGQTAL
  MLGVSHDREDMVQALLSCQADVNLQDHDGSSALMVACHHGNVDLVRLLLAHPACDSSLTDKAGRTALSIALKSPT
  HMEIAGLLRAHAEQGRSLGL

• Structural information:
  • Interpro: IPR002110  IPR020683  IPR036770  IPR021939  
  • Prosite: PS50297 PS50088
  • STRING: ENSP00000360195
• Other Databases: GeneCards:  KANK4  Malacards:  KANK4

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0030837	negative regulation of actin filament polymerization	IBA	biological process
GO:0005856	cytoskeleton	IBA	cellular component
GO:0005737	cytoplasm	IBA	cellular component
GO:0005737	cytoplasm	IDA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0005829	cytosol	IDA	cellular component
GO:0015630	microtubule cytoskeleton	IDA	cellular component

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)