• Gene id: 162517

Gene Summary

• Gene Symbol: FBXO39   Gene   UCSC   Ensembl
• Aliases: CT144, FBOX39, Fbx39
• Gene name: F-box protein 39
• Alternate names: F-box only protein 39,
• Gene location: 17p13.1 (6776214: 6787645)     Exons: 2     NC_000017.11
• Gene summary(Entrez): Members of the F-box protein family, such as FBXO39, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box pr
• OMIM: 609106

Protein Summary

• Protein general information: Q8N4B4  
  • Name: F box only protein 39
  • Length: 442  
  • Mass: 52646
• Sequence:

  MDEESELIQPQDQSCWAFLPDLCLCRVFWWLGDRDRSRAALVCRKWNQMMYSAELWRYRTITFSGRPSRVHASEV
  ESAVWYVKKFGRYLEHLEVKFMNPYNAVLTKKFQVTMRGLLSCLSKSNNRLKSLSIQYLELDRLVWRNSIRSSFI
  SSLSFFLKKMGKRLDYLNLKGARLTVEQGCQILDSLSYMRNENVISELNIEDYFSHHLAVYNSPQFKKTMSTFHN
  LVSLNLNYNCISDELLENLCENASTLRTINIKCHVHDPHGQVIWGMSWAKLARQATNLKVNFFFERIMKYERLAR
  ILLQEIPIRSISLRSCYFSDPDCSMRPTLIDLLPTFRHTLQKLTCEFNNNHESLDEELHLLIISCRKLFYFKIWA
  FLDVSFVERILKSQKERQCALRVFKARIYTNRYETNEEDKTLQEIYRKYRKLIESELSYFVIVYSVM

• Structural information:
  • Protein Domains: (16..6-)
    (/note="F-box"-)
  • Interpro: IPR036047  IPR001810  IPR001611  IPR032675  
  • Prosite: PS51450
  • STRING: ENSP00000321386
• Other Databases: GeneCards:  FBXO39  Malacards:  FBXO39

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	IBA	biological process
GO:0019005	SCF ubiquitin ligase complex	IBA	cellular component
GO:0005515	protein binding	IPI	molecular function

Diseases

Associated diseases	References
Non obstructive azoospermia	MIK: 24012201

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
24012201	Non obstructive azoospermia			31 (4 controls, 27 cases)	Male infertility	GSE45885 analyzed by GEO2R (cutoff 1.5 fold)