• Gene id: 162282

Gene Summary

• Gene Symbol: ANKFN1   Gene   UCSC   Ensembl
• Gene name: ankyrin repeat and fibronectin type III domain containing 1
• Alternate names: ankyrin repeat and fibronectin type-III domain-containing protein 1,
• Gene location: 17q22 (56110934: 56517015)     Exons: 40     NC_000017.11

Protein Summary

• Protein general information: Q8N957  
  • Name: Ankyrin repeat and fibronectin type III domain containing protein 1
  • Length: 763  
  • Mass: 87604
• Sequence:

  MEASLTRRLLFKDRHFTCSKIIGRRFACFAQRLSHRRKQSQCDLLNESTGQLPTTCSSAASNSINWNCRVKMTQQ
  MQNLHLCQSKKHSAPSSPNAAKRLYRNLSEKLKGSHSSFDEAYFRTRTDRLSLRKTSVNFQGNEAMFEAVEQQDM
  DAVQILLYQYTPEELDLNTPNSEGLTPLDIAIMTNNVPIARILLRTGARESPHFVSLESRAMHLNTLVQEAQERV
  SELSAQVENEGFTLDNTEKEKQLKAWEWRYRLYRRMKTGFEHARAPEMPTNVCLMVTSSTSLTVSFQEPLSVNAA
  VVTRYKVEWSMSEDFSPLAGEIIMDNLQTLRCTITGLTMGQQYFVQVSAYNMKGWGPAQTTTPACASPSNWKDYD
  DREPRHKGQSEVLEGLLQQVRALHQHYSCRESTKLQTTGRKQSVSRSLKHLFHSSNKFVKTLKRGLYIAVIFYYK
  DNILVTNEDQVPIVEIDDSHTSSITQDFLWFTKLSCMWEDIRWLRQSIPISSSSSTVLQTRQKMLAATAQLQNLL
  GTHNLGRVYYEPIKDRHGNILIVTIREVEMLYSFFNGKWMQISKLQSQRKSLSTPEEPTALDILLITIQDILSYH
  KRSHQRLFPGLYLGYLKLCSSVDQIKVLVTQKLPNILCHVKIRENNNISREEWEWIQKLSGSESMESVDHTSDCP
  MQLFFYELQMAVKALLQQINIPLHQARNFRLYTQEVLEMGHNVSFLLLLPASDDVCTAPGQNNPYTPHSGFLNLP
  LQMFELGIVACFT

• Structural information:
  • Protein Domains: (273..36-)
    (/note="Fibronectin-type-III)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00316"-)
  • Interpro: IPR039269  IPR002110  IPR020683  IPR036770  IPR003961   IPR036116  IPR013783  
  • Prosite: PS50297 PS50088 PS50853
  • CDD: cd00063
  • STRING: ENSP00000321627
• Other Databases: GeneCards:  ANKFN1  Malacards:  ANKFN1

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)