• Gene id: 158401

Gene Summary

• Gene Symbol: SHOC1   Gene   UCSC   Ensembl
• Aliases: C9orf84, MZIP2, ZIP2, ZIP2H
• Gene name: shortage in chiasmata 1
• Alternate names: protein shortage in chiasmata 1 ortholog, uncharacterized protein C9orf84,
• Gene location: 9q31.3 (111795948: 111686170)     Exons: 32     NC_000009.12
• OMIM: 618038

Protein Summary

• Protein general information: Q5VXU9  
  • Name: Protein shortage in chiasmata 1 ortholog (EC 3.6. . )
  • Length: 1444  
  • Mass: 165202
• Sequence:

  MTDTSVLDQWKASFFVEDFLEKKTITRMVTQINCEFEEVVPSSNPDSQIEVEEVSLYTHMDYNEVFTPVSCLEKC
  SALQNQNQDLFIDDKGILFVSSRKHLPTLPTLLSRLKLFLVKDPLLDFKGQIFTEANFSRECFSLQETLEAFVKE
  DFCMDKVNFCQEKLEDTICLNEPSSFLIEYEFLIPPSLKPEIDIPSLSELKELLNPVPEIINYVDEKEKLFERDL
  TNKHGIEDIGDIKFSSTEILTIQSQSEPEECSKPGELEMPLTPLFLTCQHSSVNSLRTELQTFPLSPVCKINLLT
  AEESANEYYMMWQLERCRSPLNPFLLTVPRIQEPHSQYSVTDLKKIFSVKEESLVINLEKAEWWKQAGLNLKMME
  TLEHLNTYLCHDNLSSNDTKIEIFLPTKVLQLESCLEHKSHSSPIALIDEKSTNAHLSLPQKSPSLAKEVPDLCF
  SDDYFSDKGAAKEEKPKNDQEPVNRIIQKKENNDHFELDCTGPSIKSPSSSIIKKASFEHGKKQENDLDLLSDFI
  MLRNKYKTCTSKTEVTNSDEKHDKEACSLTLQEESPIVHINKTLEEINQERGTDSVIEIQASDSQCQAFCLLEAA
  ASPILKNLVSLCTLPTANWKFATVIFDQTRFLLKEQEKVVSDAVRQGTIDEREMTFKHAALLHLLVTIRDVLLTC
  SLDTALGYLSKAKDIYNSILGPYLGDIWRQLEIVQFIRGKKPETNYKIQELQCQILSWMQSQQQIKVLIIIRMDS
  DGEKHFLIKILNKIEGLTLTVLHSNERKDFLESEGVLRGTSSCVVVHNQYIGADFPWSNFSFVVEYNYVEDSCWT
  KHCKELNIPYMAFKVILPDTVLERSTLLDRFGGFLLEIQIPYVFFASEGLLNTPDILQLLESNYNISLVERGCSE
  SLKLFGSSECYVVVTIDEHTAIILQDLEELNYEKASDNIIMRLMALSLQYRYCWIILYTKETLNSEYLLTEKTLH
  HLALIYAALVSFGLNSEELDVKLIIAPGVEATALIIRQIADHSLMTSKRDPHEWLDKSWLKVSPSEEEMYLLDFP
  CINPLVAQLMLNKGPSLHWILLATLCQLQELLPEVPEKVLKHFCSITSLFKIGSSSITKSPQISSPQENRNQIST
  LSSQSSASDLDSVIQEHNEYYQYLGLGETVQEDKTTILNDNSSIMELKEISSFLPPVTSYNQTSYWKDSSCKSNI
  GQNTPFLINIESRRPAYNSFLNHSDSESDVFSLGLTQMNCETIKSPTDTQKRVSVVPRFINSQKRRTHEAKGFIN
  KDVSDPIFSLEGTQSPLHWNFKKNIWEQENHPFNLQYGAQQTACNKLYSQKGNLFTDQQKCLSDESEGLTCESSK
  DETFWRELPSVPSLDLFRASDSNANQKEFNSLYFYQRAGKSLGQKRHHESSFNSGDKESLTGFMCSQLPQFKKRR
  LAYEKVPGRVDGQTRLRFF

• Structural information:
  • Interpro: IPR039991  
  • STRING: ENSP00000363405
• Other Databases: GeneCards:  SHOC1  Malacards:  SHOC1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0016887	ATPase activity	IDA	molecular function
GO:0003697	single-stranded DNA binding	IDA	molecular function
GO:0000794	condensed nuclear chromosome	ISS	cellular component
GO:0000712	resolution of meiotic recombination intermediates	ISS	biological process
GO:0000794	condensed nuclear chromosome	IEA	cellular component
GO:0000712	resolution of meiotic recombination intermediates	IEA	biological process
GO:0016887	ATPase activity	IEA	molecular function
GO:0051321	meiotic cell cycle	IEA	biological process
GO:0016787	hydrolase activity	IEA	molecular function
GO:0005694	chromosome	IEA	cellular component
GO:0003677	DNA binding	IEA	molecular function
GO:0000794	condensed nuclear chromosome	IEA	cellular component
GO:0000712	resolution of meiotic recombination intermediates	IEA	biological process
GO:0005694	chromosome	IEA	cellular component

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881