• Gene id: 158038

Gene Summary

• Gene Symbol: LINGO2   Gene   UCSC   Ensembl
• Aliases: LERN3, LRRN6C
• Gene name: leucine rich repeat and Ig domain containing 2
• Alternate names: leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2, leucine rich repeat neuronal 6C, leucine-rich repeat neuronal protein 3, leucine-rich repeat neuronal protein 6C,
• Gene location: 9p21.2-p21.1 (29215242: 27937616)     Exons: 15     NC_000009.12
• OMIM: 609793

SNPs

rs12339229

Strand:    Allele origin:   Allele change:   Mutation type: snv

NC_000009.12   g.28093234C>T
NC_000009.11   g.28093232C>T|SEQ=[C/T]|GENE=LINGO2

Protein Summary

• Protein general information: Q7L985  
  • Name: Leucine rich repeat and immunoglobulin like domain containing nogo receptor interacting protein 2 (Leucine rich repeat neuronal protein 3) (Leucine rich repeat neuronal protein 6C)
  • Length: 606  
  • Mass: 68066
• Sequence:

  MLHTAISCWQPFLGLAVVLIFMGSTIGCPARCECSAQNKSVSCHRRRLIAIPEGIPIETKILDLSKNRLKSVNPE
  EFISYPLLEEIDLSDNIIANVEPGAFNNLFNLRSLRLKGNRLKLVPLGVFTGLSNLTKLDISENKIVILLDYMFQ
  DLHNLKSLEVGDNDLVYISHRAFSGLLSLEQLTLEKCNLTAVPTEALSHLRSLISLHLKHLNINNMPVYAFKRLF
  HLKHLEIDYWPLLDMMPANSLYGLNLTSLSVTNTNLSTVPFLAFKHLVYLTHLNLSYNPISTIEAGMFSDLIRLQ
  ELHIVGAQLRTIEPHSFQGLRFLRVLNVSQNLLETLEENVFSSPRALEVLSINNNPLACDCRLLWILQRQPTLQF
  GGQQPMCAGPDTIRERSFKDFHSTALSFYFTCKKPKIREKKLQHLLVDEGQTVQLECSADGDPQPVISWVTPRRR
  FITTKSNGRATVLGDGTLEIRFAQDQDSGMYVCIASNAAGNDTFTASLTVKGFASDRFLYANRTPMYMTDSNDTI
  SNGTNANTFSLDLKTILVSTAMGCFTFLGVVLFCFLLLFVWSRGKGKHKNSIDLEYVPRKNNGAVVEGEVAGPRR
  FNMKMI

• Structural information:
  • Protein Domains: (28..5-)
    (/note="LRRNT-)
    (355..40-)
    (/note="LRRCT-)
    (410..49-)
    (/note="Ig-like-C2-type")
  • Interpro: IPR007110  IPR036179  IPR013783  IPR013098  IPR003599   IPR003598  IPR001611  IPR003591  IPR032675  IPR000372  
  • Prosite: PS50835 PS51450
  • STRING: ENSP00000369328
• Other Databases: GeneCards:  LINGO2  Malacards:  LINGO2

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005615	extracellular space	IBA	cellular component
GO:0031012	extracellular matrix	IBA	cellular component
GO:0016021	integral component of membrane	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0051965	positive regulation of synapse assembly	IEA	biological process
GO:0016020	membrane	IEA	cellular component

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq