• Gene id: 157777

Gene Summary

• Gene Symbol: MCMDC2   Gene   UCSC   Ensembl
• Aliases: C8orf45
• Gene name: minichromosome maintenance domain containing 2
• Alternate names: minichromosome maintenance domain-containing protein 2, MCM domain-containing protein 2, MCM domain-containing protein C8orf45,
• Gene location: 8q13.1 (66870756: 66926435)     Exons: 19     NC_000008.11
• OMIM: 602868

Protein Summary

• Protein general information: Q4G0Z9  
  • Name: Minichromosome maintenance domain containing protein 2 (MCM domain containing protein 2)
  • Length: 681  
  • Mass: 76219
• Sequence:

  MSNLKMKEAALIYLDRSGGLQKFIDDCKYYNDSKQSYAVYRFKILINPSDVVELDAELGNHILHQPLKAAEVFQS
  VCFIAVKTLSLIGQLQTETQINIVLKLTHLPPLPSYGLDLCEFPLDYTSQRFYMMQGIVIAMTTITKYTQGARFL
  CSDEACPLSKGFQYIRVHVPGATESATIRNDFLCNLCASSLQEDRKFRVLGDKQIVEIIATKALRAFQGYSNNQP
  FRFQSLTIFLRDESVNKMNIGNEYKIIGIPTCVKTSQTAVCIEANSITFCNSKVPSGISDNFRCLLSLTSSSCWK
  FTAILANIFASQITPPGTYNLLKLCLLMSLVQTTDRNKELEDCLDILIITSDTLLIDRLLNFSINLVPRGIRHLV
  STEIFPTLSRNKYGTGAVSIQAGSALLAKGGICFIGDLASHKKDKLEQLQTVLESRSITVYIPGKKFGEDIDQQM
  TFPVQCSFWSFVDVDSSSRRNAQKINTLIGQMDCSLIPANLVEAFGLLINCNESSPCHPFLPTVQHTLNKAINPE
  GLFYAASRQFTTEDFEKLLAFAKNLNVEFSLEAERMTHGYYLASRRIRTGSVCGSKLSASALKYLVFLSEAHARL
  NLRNKVLKEDVLIAALLFETSLTLKYGATVFCVAPNAVFPFELYNEEYLEQRDLYLTQCQQQLEQFIATYGPGTT
  IFSSDE

• Structural information:
  • Protein Domains: (533..62-)
    (/note="MCM"-)
  • Interpro: IPR031327  IPR001208  IPR041562  
  • STRING: ENSP00000413632
• Other Databases: GeneCards:  MCMDC2  Malacards:  MCMDC2

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0003688	DNA replication origin binding	IBA	molecular function
GO:0042555	MCM complex	IBA	cellular component
GO:0003697	single-stranded DNA binding	IBA	molecular function
GO:0005634	nucleus	IBA	cellular component
GO:0003677	DNA binding	IEA	molecular function
GO:0005524	ATP binding	IEA	molecular function
GO:0006270	DNA replication initiation	IEA	biological process
GO:0006281	DNA repair	IEA	biological process
GO:0051321	meiotic cell cycle	IEA	biological process
GO:0006974	cellular response to DNA damage stimulus	IEA	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0048477	oogenesis	IEA	biological process
GO:0007283	spermatogenesis	IEA	biological process
GO:0007146	meiotic recombination nodule assembly	IEA	biological process
GO:1990918	double-strand break repair involved in meiotic recombination	IEA	biological process
GO:0042140	late meiotic recombination nodule assembly	IEA	biological process
GO:0007130	synaptonemal complex assembly	IEA	biological process

Diseases

Associated diseases	References
Unexplained infertility	MIK: 25753583

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
25753583	Unexplained infertility			46 (17 fertile men, 29 male patients)	Male infertility	Microarray