• Gene id: 1538

Gene Summary

• Gene Symbol: CYLC1   Gene   UCSC   Ensembl
• Aliases: CYCL1
• Gene name: cylicin 1
• Alternate names: cylicin-1, cylicin I, cylicin, basic protein of sperm head cytoskeleton 1, multiple-band polypeptide I,
• Gene location: Xq21.1 (83861125: 83886699)     Exons: 5     NC_000023.11
• Gene summary(Entrez): This gene encodes a sperm head cytoskeletal protein. The encoded protein is associated with the calyx of spermatozoa and spermatids. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]
• OMIM: 300768

Protein Summary

• Protein general information: P35663  
  • Name: Cylicin 1 (Cylicin I) (Multiple band polypeptide I)
  • Length: 651  
  • Mass: 74242
  • Tissue specificity: Testis.
• Sequence:

  MSLPRLLKVNIRTYDNSIPISESSRKSWNQKHFALTFPKPLQRGTNDKSRPLKSQITVTRHDKRKLEEGQKPAHK
  WIRHSFRKILQWPPIYTAAREQTPFRHLYTSKTHLKKAEYKKSKDEKGGTPLKKDSKKKGGSYATNPESKQIVEE
  KTKRQNEADKTPLKSSHENEQSKKSKSSSETNPESQNSKTVSKNCSQKDKKDSKNSKKTNTEFLHTKNNPKKDLK
  RSKTSNDPISEICSENSLNVDFLMLVGQSDDESINFDAWLRNYSQNNSKNYSLKYTKYTKKDTKKNAKKSSDAES
  EDSKDAKKDSKKVKKNVKKDDKKKDVKKDTESTDAESGDSKDERKDTKKDKKKLKKDDKKKDTKKYPESTDTESG
  DAKDARNDSRNLKKASKNDDKKKDAKKITFSTDSESELESKESQKDEKKDKKDSKTDNKKSVKNDEESTDADSEP
  KGDSKKGKKDEKKGKKDSKKDDKKKDAKKNAESTEMESDLELKKDKKHSKEKKGSKKDIKKDARKDTESTDAEFD
  ESSKTGFKTSTKIKGSDTESEESLYKPGAKKKIDESDGTSANSKMEGLESKRGFRMSSKKTTFNEKGEKASTGRV
  PPSREKPPLPACEPSLPSPKVRRLCWCKMPPPPPKPRYAPLPEAPWIHKLL

• Structural information:
  • Interpro: IPR026189  IPR029354  
  • STRING: ENSP00000331556
• Other Databases: GeneCards:  CYLC1  Malacards:  CYLC1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0043159	acrosomal matrix	IBA	cellular component
GO:0005200	structural constituent of cytoskeleton	IEA	molecular function
GO:0007283	spermatogenesis	IEA	biological process
GO:0030154	cell differentiation	IEA	biological process
GO:0005737	cytoplasm	IEA	cellular component
GO:0007275	multicellular organism development	IEA	biological process
GO:0005856	cytoskeleton	IEA	cellular component
GO:0043159	acrosomal matrix	IDA	cellular component
GO:0033150	cytoskeletal calyx	IEA	cellular component
GO:0007010	cytoskeleton organization	IEA	biological process
GO:0005634	nucleus	HDA	cellular component
GO:0007283	spermatogenesis	NAS	biological process
GO:0005198	structural molecule activity	NAS	molecular function

Diseases

Associated diseases	References
Spermatogenic defects	MIK: 31037746
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
31037746	Spermatogenic defects			28 men with azoospermia	Male infertility	Microarray