• Gene id: 152110

Gene Summary

• Gene Symbol: NEK10   Gene   UCSC   Ensembl
• Aliases: CILD44
• Gene name: NIMA related kinase 10
• Alternate names: serine/threonine-protein kinase Nek10, NIMA (never in mitosis gene a)- related kinase 10, never in mitosis A-related kinase 10, nimA-related protein kinase 10,
• Gene location: 3p24.1 (27369459: 27107335)     Exons: 47     NC_000003.12
• OMIM: 618726

Protein Summary

• Protein general information: Q6ZWH5  
  • Name: Serine/threonine protein kinase Nek10 (EC 2.7.11.1) (Never in mitosis A related kinase 10) (NimA related protein kinase 10)
  • Length: 1172  
  • Mass: 133259
• Sequence:

  MPDQDKKVKTTEKSTDKQQEITIRDYSDLKRLRCLLNVQSSKQQLPAINFDSAQNSMTKSEPAIRAGGHRARGQW
  HESTEAVELENFSINYKNERNFSKHPQRKLFQEIFTALVKNRLISREWVNRAPSIHFLRVLICLRLLMRDPCYQE
  ILHSLGGIENLAQYMEIVANEYLGYGEEQHTVDKLVNMTYIFQKLAAVKDQREWVTTSGAHKTLVNLLGARDTNV
  LLGSLLALASLAESQECREKISELNIVENLLMILHEYDLLSKRLTAELLRLLCAEPQVKEQVKLYEGIPVLLSLL
  HSDHLKLLWSIVWILVQVCEDPETSVEIRIWGGIKQLLHILQGDRNFVSDHSSIGSLSSANAAGRIQQLHLSEDL
  SPREIQENTFSLQAACCAALTELVLNDTNAHQVVQENGVYTIAKLILPNKQKNAAKSNLLQCYAFRALRFLFSME
  RNRPLFKRLFPTDLFEIFIDIGHYVRDISAYEELVSKLNLLVEDELKQIAENIESINQNKAPLKYIGNYAILDHL
  GSGAFGCVYKVRKHSGQNLLAMKEVNLHNPAFGKDKKDRDSSVRNIVSELTIIKEQLYHPNIVRYYKTFLENDRL
  YIVMELIEGAPLGEHFSSLKEKHHHFTEERLWKIFIQLCLALRYLHKEKRIVHRDLTPNNIMLGDKDKVTVTDFG
  LAKQKQENSKLTSVVGTILYSCPEVLKSEPYGEKADVWAVGCILYQMATLSPPFYSTNMLSLATKIVEAVYEPVP
  EGIYSEKVTDTISRCLTPDAEARPDIVEVSSMISDVMMKYLDNLSTSQLSLEKKLERERRRTQRYFMEANRNTVT
  CHHELAVLSHETFEKASLSSSSSGAASLKSELSESADLPPEGFQASYGKDEDRACDEILSDDNFNLENAEKDTYS
  EVDDELDISDNSSSSSSSPLKESTFNILKRSFSASGGERQSQTRDFTGGTGSRPRPALLPLDLLLKVPPHMLRAH
  IKEIEAELVTGWQSHSLPAVILRNLKDHGPQMGTFLWQASAGIAVSQRKVRQISDPIQQILIQLHKIIYITQLPP
  ALHHNLKRRVIERFKKSLFSQQSNPCNLKSEIKKLSQGSPEPIEPNFFTADYHLLHRSSGGNSLSPNDPTGLPTS
  IELEEGITYEQMQTVIEEVLEESGYYNFTSNRYHSYPWGTKNHPTKR

• Structural information:
  • Protein Domains: (519..71-)
    (/note="Protein-kinase)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00159"-)
  • Interpro: IPR016024  IPR011009  IPR042666  IPR000719  IPR017441   IPR008266  
  • Prosite: PS00107 PS50011 PS00109
  • CDD: cd08528
  • STRING: ENSP00000343847
• Other Databases: GeneCards:  NEK10  Malacards:  NEK10

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:1902749	regulation of cell cycle G2/M phase transition	IBA	biological process
GO:0043406	positive regulation of MAP kinase activity	IBA	biological process
GO:0004674	protein serine/threonine kinase activity	IBA	molecular function
GO:0004672	protein kinase activity	IEA	molecular function
GO:0004674	protein serine/threonine kinase activity	IEA	molecular function
GO:0005524	ATP binding	IEA	molecular function
GO:0006468	protein phosphorylation	IEA	biological process
GO:0016740	transferase activity	IEA	molecular function
GO:0016301	kinase activity	IEA	molecular function
GO:0046872	metal ion binding	IEA	molecular function
GO:0004674	protein serine/threonine kinase activity	IEA	molecular function
GO:0016310	phosphorylation	IEA	biological process
GO:0000166	nucleotide binding	IEA	molecular function
GO:0005524	ATP binding	IEA	molecular function
GO:0006468	protein phosphorylation	IDA	biological process
GO:0004672	protein kinase activity	IDA	molecular function
GO:1902911	protein kinase complex	IDA	cellular component
GO:0031954	positive regulation of protein autophosphorylation	IDA	biological process
GO:1902749	regulation of cell cycle G2/M phase transition	IMP	biological process
GO:0070372	regulation of ERK1 and ERK2 cascade	IMP	biological process
GO:0043406	positive regulation of MAP kinase activity	IMP	biological process

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269
Unexplained infertility	MIK: 25753583

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
25753583	Unexplained infertility			46 (17 fertile men, 29 male patients)	Male infertility	Microarray