• Gene id: 151649

Gene Summary

• Gene Symbol: PP2D1   Gene   UCSC   Ensembl
• Aliases: C3orf48
• Gene name: protein phosphatase 2C like domain containing 1
• Alternate names: protein phosphatase 2C-like domain-containing protein 1,
• Gene location: 3p24.3 (20012263: 19979960)     Exons: 5     NC_000003.12
• OMIM: 613433

Protein Summary

• Protein general information: A8MPX8  
  • Name: Protein phosphatase 2C like domain containing protein 1
  • Length: 630  
  • Mass: 71643
• Sequence:

  MSTNNALRVFWKSREWNMKTSTFDSDEDILLLPKRKRFRKKKSRPVRHTKRHEEEQVYEQGTTLPCSICKHEIDL
  TGIFLHKKQHVALATLGFQWMGRKKPQPSVIAVQRQFMISKLLSSFMFTEKTLQSINNAFELLWKKQIPAYYKIF
  DNIDRSVIYSQKICHLLIKGVGICEDRNSTWKADMNDKFTVVSNFGNKPNVCFFGLFDGHHGASAAELTSMELPV
  LLLHQLSKFDPSYQMTTDEQQIINSFYTVFREEYAAIEDLFSAINKTEAVRCEYEDTHKAFAKAFWRMDRLLGLG
  RKEVSRVQWSGCSAVTCILEGKPKSPYAHKNWKRKNTHDGLAESSPSQEMPKIISGILHVANTGNVQAVLCRNGK
  GFCLTKEHTTRNTNERRRILQNGAVISSNEPYGLVEGQVKTTRGLGFHGNLKLKKSIIPAPQTISVPIDDLCQFL
  IVATNGLWEVLDKEEVTALAMTTFHMYKETYCPIIPNKSPSKGPLLFSTSEPNLTKSQSNIHVLFQYKSVSEVRV
  STTNSKENLSDSNYSKYCIYNPENVETFPAETTHRKPCSEKVTDRPTSVNDVATNEKESDTKSFYEGAAEYVSHE
  LVNAALLAGSRDNITVMVIFLNGSEYQLLT

• Structural information:
  • Protein Domains: (170..62-)
    (/note="PPM-type-phosphatase)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU01082"-)
  • Interpro: IPR015655  IPR036457  IPR001932  
  • Prosite: PS51746
  • CDD: cd00143
  • STRING: ENSP00000373702
• Other Databases: GeneCards:  PP2D1  Malacards:  PP2D1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:1990439	MAP kinase serine/threonine phosphatase activity	IBA	molecular function
GO:0004724	magnesium-dependent protein serine/threonine phosphatase activity	IBA	molecular function
GO:0004722	protein serine/threonine phosphatase activity	IBA	molecular function
GO:0006470	protein dephosphorylation	IEA	biological process
GO:0003824	catalytic activity	IEA	molecular function
GO:0004722	protein serine/threonine phosphatase activity	IEA	molecular function
GO:0000188	inactivation of MAPK activity	IEA	biological process

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)