• Gene id: 151613

Gene Summary

• Gene Symbol: TTC14   Gene   UCSC   Ensembl
• Aliases: DRDL5813, PRO19630
• Gene name: tetratricopeptide repeat domain 14
• Alternate names: tetratricopeptide repeat protein 14, TPR repeat protein 14,
• Gene location: 3q26.33 (180602162: 180618328)     Exons: 13     NC_000003.12
• OMIM: 0

Protein Summary

• Protein general information: Q96N46  
  • Name: Tetratricopeptide repeat protein 14 (TPR repeat protein 14)
  • Length: 770  
  • Mass: 88319
• Sequence:

  MDRDLLRQSLNCHGSSLLSLLRSEQQDNPHFRSLLGSAAEPARGPPPQHPLQGRKEKRVDNIEIQKFISKKADLL
  FALSWKSDAPATSEINEDSEDHYAIMPPLEQFMEIPSMDRRELFFRDIERGDIVIGRISSIREFGFFMVLICLGS
  GIMRDIAHLEITALCPLRDVPSHSNHGDPLSYYQTGDIIRAGIKDIDRYHEKLAVSLYSSSLPPHLSGIKLGVIS
  SEELPLYYRRSVELNSNSLESYENVMQSSLGFVNPGVVEFLLEKLGIDESNPPSLMRGLQSKNFSEDDFASALRK
  KQSASWALKCVKIGVDYFKVGRHVDAMNEYNKALEIDKQNVEALVARGALYATKGSLNKAIEDFELALENCPTHR
  NARKYLCQTLVERGGQLEEEEKFLNAESYYKKALALDETFKDAEDALQKLHKYMQKSLELREKQAEKEEKQKTKK
  IETSAEKLRKLLKEEKRLKKKRRKSTSSSSVSSADESVSSSSSSSSSGHKRHKKHKRNRSESSRSSRRHSSRASS
  NQIDQNRKDECYPVPANTSASFLNHKQEVEKLLGKQDRLQYEKTQIKEKDRCPLSSSSLEIPDDFGGRSEDPRDF
  YNSYKTQAGSSKTEKPYKSERHFSSRRNSSDSFCRNSEDKIYGYRRFEKDIEGRKEHYRRWEPGSVRHSTSPASS
  EYSWKSVEKYKKYAHSGSRDFSRHEQRYRLNTNQGEYEREDNYGEDIKTEVPEEDALSSKEHSESSVKKNLPQNL
  LNIFNQIAEFEKEKGNKSKN

• Structural information:
  • Protein Domains: (126..20-)
    (/note="S1-motif)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00180"-)
  • Interpro: IPR012340  IPR003029  IPR013026  IPR011990  IPR019734   IPR039190  
  • Prosite: PS50126 PS50005 PS50293
  • STRING: ENSP00000296015
• Other Databases: GeneCards:  TTC14  Malacards:  TTC14

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0003676	nucleic acid binding	IEA	molecular function

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Spermatogenic defects	MIK: 31037746
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
31037746	Spermatogenic defects			16 (1 control, 15 cases)	Male infertility	GSE6023 analyzed using GEO2R