• Gene id: 151531

Gene Summary

• Gene Symbol: UPP2   Gene   UCSC   Ensembl
• Aliases: UDRPASE2, UP2, UPASE2
• Gene name: uridine phosphorylase 2
• Alternate names: uridine phosphorylase 2, UPase 2, liver-specific uridine phosphorylase, urdPase 2,
• Gene location: 2q24.1 (157995178: 158136153)     Exons: 13     NC_000002.12
• OMIM: 607891

Protein Summary

• Protein general information: O95045  
  • Name: Uridine phosphorylase 2 (UPase 2) (UrdPase 2) (EC 2.4.2.3)
  • Length: 317  
  • Mass: 35527
  • Tissue specificity: Predominantly expressed in kidney. {ECO
• Sequence:

  MASVIPASNRSMRSDRNTYVGKRFVHVKNPYLDLMDEDILYHLDLGTKTHNLPAMFGDVKFVCVGGSPNRMKAFA
  LFMHKELGFEEAEEDIKDICAGTDRYCMYKTGPVLAISHGMGIPSISIMLHELIKLLHHARCCDVTIIRIGTSGG
  IGIAPGTVVITDIAVDSFFKPRFEQVILDNIVTRSTELDKELSEELFNCSKEIPNFPTLVGHTMCTYDFYEGQGR
  LDGALCSFSREKKLDYLKRAFKAGVRNIEMESTVFAAMCGLCGLKAAVVCVTLLDRLDCDQINLPHDVLVEYQQR
  PQLLISNFIRRRLGLCD

• Structural information:
  • Interpro: IPR018016  IPR000845  IPR035994  IPR010059  
  • Prosite: PS01232
  • PDB: 2XRF 3P0E 3P0F
  • PDBsum: 2XRF 3P0E 3P0F
  • STRING: ENSP00000474090
• Other Databases: GeneCards:  UPP2  Malacards:  UPP2

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0009116	nucleoside metabolic process	IEA	biological process
GO:0003824	catalytic activity	IEA	molecular function
GO:0004850	uridine phosphorylase activity	IEA	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0009166	nucleotide catabolic process	IEA	biological process
GO:0016763	transferase activity, transferring pentosyl groups	IEA	molecular function
GO:0016740	transferase activity	IEA	molecular function
GO:0016757	transferase activity, transferring glycosyl groups	IEA	molecular function
GO:0004850	uridine phosphorylase activity	IEA	molecular function
GO:0043097	pyrimidine nucleoside salvage	TAS	biological process
GO:0046135	pyrimidine nucleoside catabolic process	TAS	biological process
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0042802	identical protein binding	IPI	molecular function
GO:0042802	identical protein binding	IPI	molecular function
GO:0042802	identical protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0044206	UMP salvage	IEA	biological process
GO:0004850	uridine phosphorylase activity	IDA	molecular function
GO:0045098	type III intermediate filament	IDA	cellular component
GO:0004850	uridine phosphorylase activity	IDA	molecular function
GO:0006218	uridine catabolic process	IDA	biological process
GO:0006218	uridine catabolic process	IDA	biological process
GO:0046108	uridine metabolic process	NAS	biological process
GO:0009116	nucleoside metabolic process	NAS	biological process
GO:0005829	cytosol	NAS	cellular component
GO:0042802	identical protein binding	IPI	molecular function

KEGG pathways

Pathway id	Pathway name
hsa01100	Metabolic pathways
hsa00983	Drug metabolism - other enzymes
hsa00240	Pyrimidine metabolism

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq