• Gene id: 151295

Gene Summary

• Gene Symbol: SLC23A3   Gene   UCSC   Ensembl
• Aliases: E2BP3, SVCT3, Yspl1
• Gene name: solute carrier family 23 member 3
• Alternate names: solute carrier family 23 member 3, E2-binding protein 3, HPC E2-binding protein 3, Na(+)/L-ascorbic acid transporter 3, sodium-dependent vitamin C transporter 3, solute carrier family 23 (nucleobase transporters), member 3,
• Gene location: 2q35 (219170028: 219161464)     Exons: 12     NC_000002.12
• OMIM: 0

Protein Summary

• Protein general information: Q6PIS1  
  • Name: Solute carrier family 23 member 3 (HPC E2 binding protein 3) (Na(+)/L ascorbic acid transporter 3) (Sodium dependent vitamin C transporter 3)
  • Length: 610  
  • Mass: 64531
• Sequence:

  MSRSPLNPSQLRSVGSQDALAPLPPPAPQNPSTHSWDPLCGSLPWGLSCLLALQHVLVMASLLCVSHLLLLCSLS
  PGGLSYSPSQLLASSFFSCGMSTILQTWMGSRLPLVQAPSLEFLIPALVLTSQKLPRAIQTPGNSSLMLHLCRGP
  SCHGLGHWNTSLQEVSGAVVVSGLLQGMMGLLGSPGHVFPHCGPLVLAPSLVVAGLSAHREVAQFCFTHWGLALL
  VILLMVVCSQHLGSCQFHVCPWRRASTSSTHTPLPVFRLLSVLIPVACVWIVSAFVGFSVIPQELSAPTKAPWIW
  LPHPGEWNWPLLTPRALAAGISMALAASTSSLGCYALCGRLLHLPPPPPHACSRGLSLEGLGSVLAGLLGSPMGT
  ASSFPNVGKVGLIQAGSQQVAHLVGLLCVGLGLSPRLAQLLTTIPLPVVGGVLGVTQAVVLSAGFSSFYLADIDS
  GRNIFIVGFSIFMALLLPRWFREAPVLFSTGWSPLDVLLHSLLTQPIFLAGLSGFLLENTIPGTQLERGLGQGLP
  SPFTAQEARMPQKPREKAAQVYRLPFPIQNLCPCIPQPLHCLCPLPEDPGDEEGGSSEPEEMADLLPGSGEPCPE
  SSREGFRSQK

• Structural information:
  • Interpro: IPR029957  IPR006043  
  • STRING: ENSP00000406546
• Other Databases: GeneCards:  SLC23A3  Malacards:  SLC23A3

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0022857	transmembrane transporter activity	IEA	molecular function
GO:0016020	membrane	IEA	cellular component
GO:0055085	transmembrane transport	IEA	biological process
GO:0016020	membrane	IEA	cellular component
GO:0016021	integral component of membrane	IEA	cellular component
GO:0016020	membrane	IEA	cellular component

Diseases

Associated diseases	References
Spermatogenic defects	MIK: 31037746
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
31037746	Spermatogenic defects			16 (1 control, 15 cases)	Male infertility	GSE6023 analyzed using GEO2R