• Gene id: 149175

Gene Summary

• Gene Symbol: MANEAL   Gene   UCSC   Ensembl
• Gene name: mannosidase endo-alpha like
• Alternate names: glycoprotein endo-alpha-1,2-mannosidase-like protein,
• Gene location: 1p34.3 (37793815: 37801605)     Exons: 4     NC_000001.11
• OMIM: 605697

Protein Summary

• Protein general information: Q5VSG8  
  • Name: Glycoprotein endo alpha 1,2 mannosidase like protein (EC 3.2.1. )
  • Length: 457  
  • Mass: 51317
• Sequence:

  MARRRRRACIALFLVLLFAFGTLMGLRTLKAPDGLPALGPGLELAPFERRPEGAPAPAARAPAAPAAPPPPPPPP
  RTADPGGSPGPAPAEAEPAPVQSLRVYSDLHAFYYSWYGSPRREGHYIHWDHVMVPHWDPKISASYPRGRHSPPD
  DLGSSFYPELGPYSSRDPEVLREHMTQLKEAAIGVLVLSWYPPGMADDNGEPSDDLVPAILDTAHQYSIQVAFHI
  QPYKGRDDITVHDNIKYIIDTYGSHGAFYRYKNSMGKSLPLFYIYDSYLTSPEAWAHLLTPNGPHSIRNTPYDGV
  FIALLVEEGHTHDILAAGFDGMYTYFASNGFSFGSSHQNWKAVKNFCDANNLMFIPSVGPGYIDTSIRPWNNHNT
  RNRVNGKYYETALQAALTVRPEIVSITSFNEWHEGTQIEKAIPKKTPTRLYLDYLPHQPSLYLELTRRWAEHFIK
  EKEQWLM

• Structural information:
  • Interpro: IPR026071  
  • CDD: cd11574
  • STRING: ENSP00000362136
• Other Databases: GeneCards:  MANEAL  Malacards:  MANEAL

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0004559	alpha-mannosidase activity	IBA	molecular function
GO:0005794	Golgi apparatus	IBA	cellular component
GO:0016798	hydrolase activity, acting on glycosyl bonds	IEA	molecular function
GO:0005794	Golgi apparatus	IEA	cellular component
GO:0016787	hydrolase activity	IEA	molecular function
GO:0016020	membrane	IEA	cellular component
GO:0016021	integral component of membrane	IEA	cellular component
GO:0000139	Golgi membrane	IEA	cellular component

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Cryptorchidism	MIK: 28606200

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq