• Gene id: 148581

Gene Summary

• Gene Symbol: UBE2U   Gene   UCSC   Ensembl
• Gene name: ubiquitin conjugating enzyme E2 U
• Alternate names: ubiquitin-conjugating enzyme E2 U, E2 ubiquitin-conjugating enzyme U, testicular tissue protein Li 216, ubiquitin carrier protein U, ubiquitin conjugating enzyme E2 U (putative), ubiquitin conjugating enzyme E2U (putative), ubiquitin-protein ligase U,
• Gene location: 1p31.3 (64202801: 64267380)     Exons: 16     NC_000001.11

Protein Summary

• Protein general information: Q5VVX9  
  • Name: Ubiquitin conjugating enzyme E2 U (EC 2.3.2.23) (E2 ubiquitin conjugating enzyme U) (Ubiquitin carrier protein U) (Ubiquitin protein ligase U)
  • Length: 321  
  • Mass: 37741
• Sequence:

  MHGRAYLLLHRDFCDLKENNYKGITAKPVSEDMMEWEVEIEGLQNSVWQGLVFQLTIHFTSEYNYAPPVVKFITI
  PFHPNVDPHTGQPCIDFLDNPEKWNTNYTLSSILLALQVMLSNPVLENPVNLEAARILVKDESLYRTILRLFNRP
  LQMKDDSQELPKDPRKCIRPIKTTSFSDYYQTWSRIATSKATEYYRTPLLKVPNFIGQYYKWKKMDLQHQKEWNL
  KYSVIKCWLARKRMPHEVTHSMEEIKLCPTLIPTTDEIFLESPTAINSITDIYETEEEGWKSDTSLYENDTDEPR
  EEEVEDLISWTNTLNTNTSED

• Structural information:
  • Interpro: IPR000608  IPR023313  IPR016135  
  • Prosite: PS00183 PS50127
  • CDD: cd00195
  • PDB: 1YRV
  • PDBsum: 1YRV
  • STRING: ENSP00000360116
• Other Databases: GeneCards:  UBE2U  Malacards:  UBE2U

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0006281	DNA repair	IBA	biological process
GO:0016574	histone ubiquitination	IBA	biological process
GO:0033503	HULC complex	IBA	cellular component
GO:0000209	protein polyubiquitination	IBA	biological process
GO:0000790	nuclear chromatin	IBA	cellular component
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	IBA	biological process
GO:0061631	ubiquitin conjugating enzyme activity	IBA	molecular function
GO:0016740	transferase activity	IEA	molecular function
GO:0005524	ATP binding	IEA	molecular function
GO:0000166	nucleotide binding	IEA	molecular function
GO:0061631	ubiquitin conjugating enzyme activity	IEA	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0016567	protein ubiquitination	IEA	biological process

KEGG pathways

Pathway id	Pathway name
hsa04120	Ubiquitin mediated proteolysis

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881