• Gene id: 148113

Gene Summary

• Gene Symbol: CILP2   Gene   UCSC   Ensembl
• Aliases: CLIP-2
• Gene name: cartilage intermediate layer protein 2
• Alternate names: cartilage intermediate layer protein 2, CILP-2, cartilage intermediate layer protein-like protein 2,
• Gene location: 19p13.11 (19538264: 19546658)     Exons: 8     NC_000019.10
• OMIM: 612694

Protein Summary

• Protein general information: Q8IUL8  
  • Name: Cartilage intermediate layer protein 2 (CILP 2) [Cleaved into: Cartilage intermediate layer protein 2 C1; Cartilage intermediate layer protein 2 C2]
  • Length: 1156  
  • Mass: 126291
  • Tissue specificity: Expressed in articular chondrocytes but not in knee meniscal cartilage cells (PubMed
• Sequence:

  MASLLPLLCLCVVAAHLAGARDATPTEEPMATALGLERRSVYTGQPSPALEDWEEASEWTSWFNVDHPGGDGDFE
  SLAAIRFYYGPARVCPRPLALEARTTDWALPSAVGERVHLNPTRGFWCLNREQPRGRRCSNYHVRFRCPLEASWG
  AWGPWGPCSGSCGPGRRLRRRHCPSPAGDACPGRPLEAQKCVRPRCPGCSLDTCECPDHILLGSVVTPSGQPLLG
  ARVSLRDQPGTVATSDAHGTFRVPGVCADSRANIRAQMDGFSAGEAQAQANGSISVVTIILDKLEKPYLVKHPES
  RVREAGQNVTFCCKASGTPMPKKYSWFHNGTLLDRRAHGYGAHLELRGLRPDQAGIYHCKAWNEAGAVRSGTARL
  TVLAPGQPACDPRPREYLIKLPEDCGQPGSGPAYLDVGLCPDTRCPSLAGSSPRCGDASSRCCSVRRLERREIHC
  PGYVLPVKVVAECGCQKCLPPRGLVRGRVVAADSGEPLRFARILLGQEPIGFTAYQGDFTIEVPPSTQRLVVTFV
  DPSGEFMDAVRVLPFDPRGAGVYHEVKAMRKKAPVILHTSQSNTIPLGELEDEAPLGELVLPSGAFRRADGKPYS
  GPVEARVTFVDPRDLTSAASAPSDLRFVDSDGELAPLRTYGMFSVDLRAPGSAEQLQVGPVAVRVAASQIHMPGH
  VEALKLWSLNPETGLWEEESGFRREGSSGPRVRREERVFLVGNVEIRERRLFNLDVPERRRCFVKVRAYANDKFT
  PSEQVEGVVVTLVNLEPAPGFSANPRAWGRFDSAVTGPNGACLPAFCDADRPDAYTALVTATLGGEELEPAPSLP
  RPLPATVGVTQPYLDRLGYRRTDHDDPAFKRNGFRINLAKPRPGDPAEANGPVYPWRSLRECQGAPVTASHFRFA
  RVEADKYEYNVVPFREGTPASWTGDLLAWWPNPQEFRACFLKVKIQGPQEYMVRSHNAGGSHPRTRGQLYGLRDA
  RSVRDPERPGTSAACVEFKCSGMLFDQRQVDRTLVTIMPQGSCRRVAVNGLLRDYLTRHPPPVPAEDPAAFSMLA
  PLDPLGHNYGVYTVTDQSPRLAKEIAIGRCFDGSSDGFSREMKADAGTAVTFQCREPPAGRPSLFQRLLESPATA
  LGDIRREMSEAAQAQARASGPLRTRRGRVRQ

• Structural information:
  • Protein Domains: (146..19-)
    (/note="TSP-type-1)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00210-)
    (292..37-)
    (/note="Ig-like-C2-type")
  • Interpro: IPR008969  IPR039675  IPR007110  IPR036179  IPR013783   IPR003599  IPR003598  IPR000884  IPR036383  IPR025155  
  • Prosite: PS50835 PS50092
  • STRING: ENSP00000291495
• Other Databases: GeneCards:  CILP2  Malacards:  CILP2

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005576	extracellular region	IEA	cellular component
GO:0004035	alkaline phosphatase activity	IDA	NOT|molecular function
GO:0004551	nucleotide diphosphatase activity	IDA	NOT|molecular function
GO:0016311	dephosphorylation	IEA	biological process
GO:0070062	extracellular exosome	HDA	cellular component

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Cryptorchidism	MIK: 28606200

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq