• Gene id: 147841

Gene Summary

• Gene Symbol: SPC24   Gene   UCSC   Ensembl
• Aliases: SPBC24
• Gene name: SPC24 component of NDC80 kinetochore complex
• Alternate names: kinetochore protein Spc24, SPC24, NDC80 kinetochore complex component, homolog, hSpc24, spindle pole body component 24 homolog,
• Gene location: 19p13.2 (14843525: 14825568)     Exons: 3     NC_000012.12
• OMIM: 609394

Protein Summary

• Protein general information: Q8NBT2  
  • Name: Kinetochore protein Spc24 (hSpc24)
  • Length: 197  
  • Mass: 22478
• Sequence:

  MAAFRDIEEVSQGLLSLLGANRAEAQQRRLLGRHEQVVERLLETQDGAEKQLREILTMEKEVAQSLLNAKEQVHQ
  GGVELQQLEAGLQEAGEEDTRLKASLLYLTRELEELKEIEADLERQEKEVDEDTTVTIPSAVYVAQLYHQVSKIE
  WDYECEPGMVKGIHHGPSVAQPIHLDSTQLSRKFISDYLWSLVDTEW

• Structural information:
  • Interpro: IPR013252  
  • PDB: 2VE7 3IZ0
  • PDBsum: 2VE7 3IZ0
  • DIP: 35754
  • STRING: ENSP00000465075
• Other Databases: GeneCards:  SPC24  Malacards:  SPC24

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0031262	Ndc80 complex	IDA	cellular component
GO:0000776	kinetochore	IEA	cellular component
GO:0051301	cell division	IEA	biological process
GO:0005694	chromosome	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0007049	cell cycle	IEA	biological process
GO:0000775	chromosome, centromeric region	IEA	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0000777	condensed chromosome kinetochore	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0005654	nucleoplasm	IDA	cellular component
GO:0005730	nucleolus	IDA	cellular component

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)