• Gene id: 146862

Gene Summary

• Gene Symbol: UNC45B   Gene   UCSC   Ensembl
• Aliases: CMYA4, CTRCT43, SMUNC45, UNC-45B, UNC45
• Gene name: unc-45 myosin chaperone B
• Alternate names: protein unc-45 homolog B, cardiomyopathy associated 4, striated muscle UNC45, unc-45 homolog B,
• Gene location: 17q12 (35147792: 35189344)     Exons: 20     NC_000017.11
• Gene summary(Entrez): This gene encodes a co-chaperone required for folding and accumulation of type II myosins. The protein consists of three tetratricopeptide repeat motifs at the N-terminus that form a complex with heat shock protein 90, a central region of unknown function
• OMIM: 614570

Protein Summary

• Protein general information: Q8IWX7  
  • Name: Protein unc 45 homolog B (Unc 45B) (SMUNC45)
  • Length: 931  
  • Mass: 103733
  • Tissue specificity: Expressed in eye lens tissues. {ECO
• Sequence:

  MAEVEAVQLKEEGNRHFQLQDYKAATNSYSQALKLTKDKALLATLYRNRAACGLKTESYVQAASDASRAIDINSS
  DIKALYRRCQALEHLGKLDQAFKDVQRCATLEPRNQNFQEMLRRLNTSIQEKLRVQFSTDSRVQKMFEILLDENS
  EADKREKAANNLIVLGREEAGAEKIFQNNGVALLLQLLDTKKPELVLAAVRTLSGMCSGHQARATVILHAVRIDR
  ICSLMAVENEEMSLAVCNLLQAIIDSLSGEDKREHRGKEEALVLDTKKDLKQITSHLLDMLVSKKVSGQGRDQAL
  NLLNKNVPRKDLAIHDNSRTIYVVDNGLRKILKVVGQVPDLPSCLPLTDNTRMLASILINKLYDDLRCDPERDHF
  RKICEEYITGKFDPQDMDKNLNAIQTVSGILQGPFDLGNQLLGLKGVMEMMVALCGSERETDQLVAVEALIHAST
  KLSRATFIITNGVSLLKQIYKTTKNEKIKIRTLVGLCKLGSAGGTDYGLRQFAEGSTEKLAKQCRKWLCNMSIDT
  RTRRWAVEGLAYLTLDADVKDDFVQDVPALQAMFELAKAGTSDKTILYSVATTLVNCTNSYDVKEVIPELVQLAK
  FSKQHVPEEHPKDKKDFIDMRVKRLLKAGVISALACMVKADSAILTDQTKELLARVFLALCDNPKDRGTIVAQGG
  GKALIPLALEGTDVGKVKAAHALAKIAAVSNPDIAFPGERVYEVVRPLVRLLDTQRDGLQNYEALLGLTNLSGRS
  DKLRQKIFKERALPDIENYMFENHDQLRQAATECMCNMVLHKEVQERFLADGNDRLKLVVLLCGEDDDKVQNAAA
  GALAMLTAAHKKLCLKMTQVTTQWLEILQRLCLHDQLSVQHRGLVIAYNLLAADAELAKKLVESELLEILTVVGK
  QEPDEKKAEVVQTARECLIKCMDYGFIKPVS

• Structural information:
  • Interpro: IPR011989  IPR016024  IPR000225  IPR013026  IPR011990   IPR019734  IPR024660  
  • Prosite: PS50005 PS50293
  • STRING: ENSP00000268876
• Other Databases: GeneCards:  UNC45B  Malacards:  UNC45B

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0061077	chaperone-mediated protein folding	IBA	biological process
GO:0051879	Hsp90 protein binding	IBA	molecular function
GO:0002088	lens development in camera-type eye	ISS	biological process
GO:0030154	cell differentiation	IEA	biological process
GO:0007517	muscle organ development	IEA	biological process
GO:0005737	cytoplasm	IEA	cellular component
GO:0007275	multicellular organism development	IEA	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0061077	chaperone-mediated protein folding	IEA	biological process
GO:0005829	cytosol	IEA	cellular component
GO:0051879	Hsp90 protein binding	IEA	molecular function
GO:0005829	cytosol	IEA	cellular component

Diseases

Associated diseases	References
Cataract	KEGG:H01202
Cataract	KEGG:H01202
Cryptorchidism	MIK: 28606200

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq