• Gene id: 143903

Gene Summary

• Gene Symbol: LAYN   Gene   UCSC   Ensembl
• Gene name: layilin
• Alternate names: layilin,
• Gene location: 11q23.1 (111540279: 111561744)     Exons: 9     NC_000011.10
• OMIM: 618843

Protein Summary

• Protein general information: Q6UX15  
  • Name: Layilin
  • Length: 382  
  • Mass: 43108
• Sequence:

  MRPGTALQAVLLAVLLVGLRAATGRLLSASDLDLRGGQPVCRGGTQRPCYKVIYFHDTSRRLNFEEAKEACRRDG
  GQLVSIESEDEQKLIEKFIENLLPSDGDFWIGLRRREEKQSNSTACQDLYAWTDGSISQFRNWYVDEPSCGSEVC
  VVMYHQPSAPAGIGGPYMFQWNDDRCNMKNNFICKYSDEKPAVPSREAEGEETELTTPVLPEETQEEDAKKTFKE
  SREAALNLAYILIPSIPLLLLLVVTTVVCWVWICRKRKREQPDPSTKKQHTIWPSPHQGNSPDLEVYNVIRKQSE
  ADLAETRPDLKNISFRVCSGEATPDDMSCDYDNMAVNPSESGFVTLVSVESGFVTNDIYEFSPDQMGRSKESGWV
  ENEIYGY

• Structural information:
  • Protein Domains: (45..18-)
    (/note="C-type-lectin)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00040"-)
  • Interpro: IPR001304  IPR016186  IPR016187  
  • Prosite: PS50041
  • STRING: ENSP00000364765
• Other Databases: GeneCards:  LAYN  Malacards:  LAYN

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005540	hyaluronic acid binding	IDA	molecular function
GO:0001726	ruffle	ISS	cellular component
GO:0005925	focal adhesion	ISS	NOT|cellular component
GO:0009986	cell surface	ISS	cellular component
GO:0005540	hyaluronic acid binding	IBA	molecular function
GO:0030246	carbohydrate binding	IEA	molecular function
GO:0016021	integral component of membrane	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0005925	focal adhesion	HDA	cellular component

Diseases

Associated diseases	References
Spermatogenic defects	MIK: 31037746
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
31037746	Spermatogenic defects			16 (1 control, 15 cases)	Male infertility	GSE6023 analyzed using GEO2R