• Gene id: 140902

Gene Summary

• Gene Symbol: R3HDML   Gene   UCSC   Ensembl
• Aliases: dJ881L22.3
• Gene name: R3H domain containing like
• Alternate names: peptidase inhibitor R3HDML, cysteine-rich secretory protein R3HDML,
• Gene location: 20q13.12 (44337042: 44351237)     Exons: 5     NC_000020.11
• OMIM: 607391

Protein Summary

• Protein general information: Q9H3Y0  
  • Name: Peptidase inhibitor R3HDML (Cysteine rich secretory protein R3HDML)
  • Length: 253  
  • Mass: 28605
• Sequence:

  MPLLPSTVGLAGLLFWAGQAVNALIMPNATPAPAQPESTAMRLLSGLEVPRYRRKRHISVRDMNALLDYHNHIRA
  SVYPPAANMEYMVWDKRLARAAEAWATQCIWAHGPSQLMRYVGQNLSIHSGQYRSVVDLMKSWSEEKWHYLFPAP
  RDCNPHCPWRCDGPTCSHYTQMVWASSNRLGCAIHTCSSISVWGNTWHRAAYLVCNYAIKGNWIGESPYKMGKPC
  SSCPPSYQGSCNSNMCFKGLKSNKFTWF

• Structural information:
  • Protein Domains: (67..20-)
    (/note="SCP"-)
  • Interpro: IPR014044  IPR035940  IPR001283  
  • STRING: ENSP00000217043
• Other Databases: GeneCards:  R3HDML  Malacards:  R3HDML

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005615	extracellular space	IBA	cellular component
GO:0010466	negative regulation of peptidase activity	IEA	biological process
GO:0030414	peptidase inhibitor activity	IEA	molecular function
GO:0005576	extracellular region	IEA	cellular component
GO:0005576	extracellular region	IEA	cellular component

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Cryptorchidism	MIK: 28606200

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq