• Gene id: 140901

Gene Summary

• Gene Symbol: STK35   Gene   UCSC   Ensembl
• Aliases: CLIK1, STK35L1
• Gene name: serine/threonine kinase 35
• Alternate names: serine/threonine-protein kinase 35, CLIK-1, CLP-36 interacting kinase, CLP-36-interacting kinase 1, PDLIM1-interacting kinase 1, serine threonine kinase 35 long form, serine/threonine-protein kinase 35 L1,
• Gene location: 20p13 (2098020: 2148554)     Exons: 4     NC_000020.11
• Gene summary(Entrez): The protein encoded by this gene is a kinase that is predominantly found in the nucleus. However, it can interact with PDLIM1/CLP-36 in the cytoplasm and localize to actin stress fibers. The encoded protein may be a regulator of actin stress fibers in non
• OMIM: 609370

Protein Summary

• Protein general information: Q8TDR2  
  • Name: Serine/threonine protein kinase 35 (EC 2.7.11.1) (CLP 36 interacting kinase 1) (CLIK 1) (PDLIM1 interacting kinase 1) (Serine/threonine protein kinase 35 L1)
  • Length: 534  
  • Mass: 58051
  • Tissue specificity: Expressed in testis.
• Sequence:

  MGHQESPLARAPAGGAAYVKRLCKGLSWREHVESHGSLGAQASPASAAAAEGSATRRARAATSRAARSRRQPGPG
  ADHPQAGAPGGKRAARKWRCAGQVTIQGPAPPRPRAGRRDEAGGARAAPLLLPPPPAAMETGKDGARRGTQSPER
  KRRSPVPRAPSTKLRPAAAARAMDPVAAEAPGEAFLARRRPEGGGGSARPRYSLLAEIGRGSYGVVYEAVAGRSG
  ARVAVKKIRCDAPENVELALAEFWALTSLKRRHQNVVQFEECVLQRNGLAQRMSHGNKSSQLYLRLVETSLKGER
  ILGYAEEPCYLWFVMEFCEGGDLNQYVLSRRPDPATNKSFMLQLTSAIAFLHKNHIVHRDLKPDNILITERSGTP
  ILKVADFGLSKVCAGLAPRGKEGNQDNKNVNVNKYWLSSACGSDFYMAPEVWEGHYTAKADIFALGIIIWAMIER
  ITFIDSETKKELLGTYIKQGTEIVPVGEALLENPKMELHIPQKRRTSMSEGIKQLLKDMLAANPQDRPDAFELET
  RMDQVTCAA

• Structural information:
  • Protein Domains: (202..53-)
    (/note="Protein-kinase)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00159"-)
  • Interpro: IPR011009  IPR000719  IPR017441  IPR008271  
  • Prosite: PS00107 PS50011 PS00108
  • STRING: ENSP00000370891
• Other Databases: GeneCards:  STK35  Malacards:  STK35

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0004672	protein kinase activity	IBA	molecular function
GO:0004672	protein kinase activity	IEA	molecular function
GO:0005524	ATP binding	IEA	molecular function
GO:0006468	protein phosphorylation	IEA	biological process
GO:0016740	transferase activity	IEA	molecular function
GO:0016301	kinase activity	IEA	molecular function
GO:0016310	phosphorylation	IEA	biological process
GO:0005634	nucleus	IEA	cellular component
GO:0004674	protein serine/threonine kinase activity	IEA	molecular function
GO:0005524	ATP binding	IEA	molecular function
GO:0000166	nucleotide binding	IEA	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005730	nucleolus	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0005654	nucleoplasm	IDA	cellular component
GO:0016604	nuclear body	IDA	cellular component

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)