• Gene id: 140894

Gene Summary

• Gene Symbol: CNBD2   Gene   UCSC   Ensembl
• Aliases: C20orf152, CNMPD1
• Gene name: cyclic nucleotide binding domain containing 2
• Alternate names: cyclic nucleotide-binding domain-containing protein 2, cyclic nucleotide (cNMP) binding domain containing 1,
• Gene location: 20q11.23 (35954560: 36030699)     Exons: 4     NC_000020.11

Protein Summary

• Protein general information: Q96M20  
  • Name: Cyclic nucleotide binding domain containing protein 2
  • Length: 576  
  • Mass: 67512
• Sequence:

  MRRHMVTYAWQLLKKELGLYQLAMDIIIMIRVCKMFRQGLRGFREYQIIETAHWKHPIFSFWDKKMQSRVTFDTM
  DFIAEEGHFPPKAIQIMQKKPSWRTEDEIQAVCNILQVLDSYRNYAEPLQLLLAKVMRFERFGRRRVIIKKGQKG
  NSFYFIYLGTVAITKDEDGSSAFLDPHPKLLHKGSCFGEMDVLHASVRRSTIVCMEETEFLVVDREDFFANKLDQ
  EVQKDAQYRFEFFRKMELFASWSDEKLWQLVAMAKIERFSYGQLISKDFGESPFIMFISKGSCEVLRLLDLGASP
  SYRRWIWQHLELIDGRPLKTHLSEYSPMERFKEFQIKSYPLQDFSSLKLPHLKKAWGLQGTSFSRKIRTSGDTLP
  KMLGPKIQSRPAQSIKCAMINIKPGELPKEAAVGAYVKVHTVEQGEILGLHQAFLPEGECDTRPLILMSLGNELI
  RIRKEIFYELIDNDDEMIKKLLKLNIAFPSDEDMCQKFLQQNSWNIFRKDLLQLLVEPCQSQLFTPNRPKKREIY
  NPKSVVLDLCSINKTTKPRYPIFMAPQKYLPPLRIVQAIKAPRYKIRELLA

• Structural information:
  • Interpro: IPR038897  IPR018490  IPR018488  IPR000595  IPR014710  
  • Prosite: PS00888 PS50042
  • CDD: cd00038
  • STRING: ENSP00000340954
• Other Databases: GeneCards:  CNBD2  Malacards:  CNBD2

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0030552	cAMP binding	IBA	molecular function
GO:0007283	spermatogenesis	IBA	biological process
GO:0005737	cytoplasm	IEA	cellular component
GO:0030552	cAMP binding	IEA	molecular function
GO:0000166	nucleotide binding	IEA	molecular function
GO:0007283	spermatogenesis	IEA	biological process
GO:0005829	cytosol	IEA	cellular component
GO:0030552	cAMP binding	IEA	molecular function
GO:0005829	cytosol	IEA	cellular component

Diseases

Associated diseases	References
Non obstructive azoospermia	MIK: 24012201
Sertoli cell only syndrome	MIK: 23869807
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
24012201	Non obstructive azoospermia			31 (4 controls, 27 cases)	Male infertility	GSE45885 analyzed by GEO2R (cutoff 1.5 fold)
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
23869807	Non obstructive azoospermia, Sertoli cell only syndrome			20 (4 controls, 16 cases)	Male infertility	GSE45887 analyzed by GEO2R (cutoff 1.5 fold)