• Gene id: 138009

Gene Summary

• Gene Symbol: DCAF4L2   Gene   UCSC   Ensembl
• Aliases: WDR21C
• Gene name: DDB1 and CUL4 associated factor 4 like 2
• Alternate names: DDB1- and CUL4-associated factor 4-like protein 2, WD repeat domain 21C, WD repeat-containing protein 21C,
• Gene location: 8q21.3 (87874014: 87870746)     Exons: 7     NC_000008.11

Protein Summary

• Protein general information: Q8NA75  
  • Name: DDB1 and CUL4 associated factor 4 like protein 2 (WD repeat containing protein 21C)
  • Length: 395  
  • Mass: 43747
• Sequence:

  MESKRPRLLEEADKQKKTVRVGLNAPSMLRKNQLGFLRFANYCRIARELRVSCMQRKKVQIHSWDPSSLASDRFN
  RILANTNTDQLFTVNQVEAGGSKYGIITMRGLTTPELRVYPHKTLYVPNRKVNSMCWASLNHLDSHLLLCFVGLA
  DTPSCAVLLPASLFIGSFPGMRRPGMLCSFQIPDAWSCAWSLSIHAYHSFSTGLSQQVLLTNVVTGHQQSFGTSS
  DVLAQQFAIMTPLLFNGCRSGEIFGIDLRCGNQGSGWKAICLSHDSAVTSLQILQDGQFLVSSDMTGTIKLWDLR
  ATKCVTQYEGHVNNSAYLPVHVNEEEGVVAAVGQDCYTRIWSLRHGHLLTTIPSPYPASENDIPSVAFSSRLGGF
  RGAPGLLMAVREDLYCFSYG

• Structural information:
  • Interpro: IPR015943  IPR001680  IPR017986  IPR036322  
  • Prosite: PS50082 PS50294
  • STRING: ENSP00000316496
• Other Databases: GeneCards:  DCAF4L2  Malacards:  DCAF4L2

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881