• Gene id: 137902

Gene Summary

• Gene Symbol: PXDNL   Gene   UCSC   Ensembl
• Aliases: PMR1, PRM1, VPO2
• Gene name: peroxidasin like
• Alternate names: peroxidasin-like protein, cardiac peroxidase, cardiovascular peroxidase 2, peroxidasin homolog-like, polysomal ribonuclease 1 homolog, vascular peroxidase 2,
• Gene location: 8q11.22-q11.23 (46759162: 46599250)     Exons: 19     NC_000023.11
• OMIM: 615904

Protein Summary

• Protein general information: A1KZ92  
  • Name: Peroxidasin like protein (EC 1.11.1.7) (Cardiac peroxidase) (Vascular peroxidase 2) (polysomal ribonuclease 1) (PRM1)
  • Length: 1463  
  • Mass: 163686
  • Tissue specificity: the 57 kDa isoform PMR1 is the only form detected at protein levels in human cell lines. {ECO
• Sequence:

  MEPRLFCWTTLFLLAGWCLPGLPCPSRCLCFKSTVRCMHLMLDHIPQVPQQTTVLDLRFNRIREIPGSAFKKLKN
  LNTLLLNNNHIRKISRNAFEGLENLLYLYLYKNEIHALDKQTFKGLISLEHLYIHFNQLEMLQPETFGDLLRLER
  LFLHNNKLSKIPAGSFSNLDSLKRLRLDSNALVCDCDLMWLGELLQGFAQHGHTQAAATCEYPRRLHGRAVASVT
  VEEFNCQSPRITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLMIRNTRESDQ
  GVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGTSTTLECMATGHPHPLITWTRDNGLELDGSR
  HVATSSGLYLQNITQRDHGRFTCHANNSHGTVQAAANIIVQAPPQFTVTPKDQVVLEEHAVEWLCEADGNPPPVI
  VWTKTGGQLPVEGQHTVLSSGTLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTVKPKALAVFTQLPQDTSVEVG
  KNINISCHAQGEPQPIITWNKEGVQITESGKFHVDDEGTLTIYDAGFPDQGRYECVARNSFGLAVTNMFLTVTAI
  QGRQAGDDFVESSILDAVQRVDSAINSTRRHLFSQKPHTSSDLLAQFHYPRDPLIVEMARAGEIFEHTLQLIRER
  VKQGLTVDLEGKEFRYNDLVSPRSLSLIANLSGCTARRPLPNCSNRCFHAKYRAHDGTCNNLQQPTWGAALTAFA
  RLLQPAYRDGIRAPRGLGLPVGSRQPLPPPRLVATVWARAAAVTPDHSYTRMLMHWGWFLEHDLDHTVPALSTAR
  FSDGRPCSSVCTNDPPCFPMNTRHADPRGTHAPCMLFARSSPACASGRPSATVDSVYAREQINQQTAYIDGSNVY
  GSSERESQALRDPSVPRGLLKTGFPWPPSGKPLLPFSTGPPTECARQEQESPCFLAGDHRANEHLALAAMHTLWF
  REHNRMATELSALNPHWEGNTVYQEARKIVGAELQHITYSHWLPKVLGDPGTRMLRGYRGYNPNVNAGIINSFAT
  AAFRFGHTLINPILYRLNATLGEISEGHLPFHKALFSPSRIIKEGGIDPVLRGLFGVAAKWRAPSYLLSPELTQR
  LFSAAYSAAVDSAATIIQRGRDHGIPPYVDFRVFCNLTSVKNFEDLQNEIKDSEIRQKLRKLYGSPGDIDLWPAL
  MVEDLIPGTRVGPTLMCLFVTQFQRLRDGDRFWYENPGVFTPAQLTQLKQASLSRVLCDNGDSIQQVQADVFVKA
  EYPQDYLNCSEIPKVDLRVWQDCCADCRSRGQFRAVTQESQKKRSAQYSYPVDKDMELSHLRSRQQDKIYVGEDA
  RNVTVLAKTKFSQDFSTFAAEIQETITALREQINKLEARLRQAGCTDVRGVPRKAEERWMKEDCTHCICESGQVT
  CVVEICPPAPCPSPELVKGTCCPVCRDRGMPSDSPEKR

• Structural information:
  • Protein Domains: (24..5-)
    (/note="LRRNT-)
    (180..23-)
    (/note="LRRCT-)
    (234..32-)
    1 (/note="Ig-like-C2-type)
    (330..41-)
    2 (/note="Ig-like-C2-type)
    (419..50-)
    3 (/note="Ig-like-C2-type)
    (507..59-)
    4 (/note="Ig-like-C2-type)
    (1393-)
  • Interpro: IPR000483  IPR019791  IPR010255  IPR037120  IPR007110   IPR036179  IPR013783  IPR013098  IPR003599  IPR003598  IPR001611  IPR003591  IPR032675  IPR034824  IPR029610  IPR001007  
  • Prosite: PS50835 PS51450 PS50292 PS01208 PS50184
  • CDD: cd09826
  • STRING: ENSP00000348645
• Other Databases: GeneCards:  PXDNL  Malacards:  PXDNL

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0004601	peroxidase activity	IBA	molecular function
GO:0005615	extracellular space	IBA	cellular component
GO:0042744	hydrogen peroxide catabolic process	ISS	biological process
GO:0055114	oxidation-reduction process	ISS	biological process
GO:0020037	heme binding	ISS	molecular function
GO:0005615	extracellular space	ISS	cellular component
GO:0004601	peroxidase activity	ISS	molecular function
GO:0004601	peroxidase activity	IEA	molecular function
GO:0020037	heme binding	IEA	molecular function
GO:0055114	oxidation-reduction process	IEA	biological process
GO:0006979	response to oxidative stress	IEA	biological process
GO:0004518	nuclease activity	IEA	molecular function
GO:0016787	hydrolase activity	IEA	molecular function
GO:0055114	oxidation-reduction process	IEA	biological process
GO:0004519	endonuclease activity	IEA	molecular function
GO:0005576	extracellular region	IEA	cellular component
GO:0004601	peroxidase activity	IEA	molecular function
GO:0046872	metal ion binding	IEA	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0016491	oxidoreductase activity	IEA	molecular function
GO:0042744	hydrogen peroxide catabolic process	IEA	biological process
GO:0004601	peroxidase activity	IEA	molecular function
GO:0005576	extracellular region	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0098869	cellular oxidant detoxification	IEA	biological process
GO:0098869	cellular oxidant detoxification	IEA	biological process
GO:0098869	cellular oxidant detoxification	IEA	biological process
GO:0098869	cellular oxidant detoxification	IEA	biological process
GO:0098869	cellular oxidant detoxification	IEA	biological process
GO:0090305	nucleic acid phosphodiester bond hydrolysis	IEA	biological process
GO:0090305	nucleic acid phosphodiester bond hydrolysis	IEA	biological process

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200
Spermatogenic defects	MIK: 31037746
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq
31037746	Spermatogenic defects			16 (1 control, 15 cases)	Male infertility	GSE6023 analyzed using GEO2R