• Gene id: 137362

Gene Summary

• Gene Symbol: GOT1L1   Gene   UCSC   Ensembl
• Gene name: glutamic-oxaloacetic transaminase 1 like 1
• Alternate names: putative aspartate aminotransferase, cytoplasmic 2, glutamate oxaloacetate transaminase 1-like protein 1, transaminase A-like protein 1,
• Gene location: 8p11.23 (37940502: 37933547)     Exons: 10     NC_000008.11

Protein Summary

• Protein general information: Q8NHS2  
  • Name: Putative aspartate aminotransferase, cytoplasmic 2 (EC 2.6.1.1) (Glutamate oxaloacetate transaminase 1 like protein 1) (Transaminase A like protein 1)
  • Length: 421  
  • Mass: 47305
• Sequence:

  MPTLSVFMDVPLAHKLEGSLLKTYKQDDYPNKIFLAYRVCMTNEGHPWVSLVVQKTRLQISQDPSLNYEYLPTMG
  LKSFIQASLALLFGKHSQAIVENRVGGVHTVGDSGAFQLGVQFLRAWHKDARIVYIISSQKELHGLVFQDMGFTV
  YEYSVWDPKKLCMDPDILLNVVEQIPHGCVLVMGNIIDCKLTPSGWAKLMSMIKSKQIFPFFDIPCQGLYTSDLE
  EDTRILQYFVSQGFEFFCSQSLSKNFGIYDEGVGMLVVVAVNNQQLLCVLSQLEGLAQALWLNPPNTGARVITSI
  LCNPALLGEWKQSLKEVVENIMLTKEKVKEKLQLLGTPGSWGHITEQSGTHGYLGLNSQQVEYLVRKKHIYIPKN
  GQINFSCINANNINYITEGINEAVLLTESSEMCLPKEKKTLIGIKL

• Structural information:
  • Interpro: IPR004839  IPR000796  IPR015424  IPR015422  IPR015421  
  • STRING: ENSP00000303077
• Other Databases: GeneCards:  GOT1L1  Malacards:  GOT1L1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0006532	aspartate biosynthetic process	IBA	biological process
GO:0004069	L-aspartate:2-oxoglutarate aminotransferase activity	IBA	molecular function
GO:0005829	cytosol	IBA	cellular component
GO:0009058	biosynthetic process	IEA	biological process
GO:0030170	pyridoxal phosphate binding	IEA	molecular function
GO:0003824	catalytic activity	IEA	molecular function
GO:0006520	cellular amino acid metabolic process	IEA	biological process
GO:0008483	transaminase activity	IEA	molecular function
GO:0016740	transferase activity	IEA	molecular function
GO:0008483	transaminase activity	IEA	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0004069	L-aspartate:2-oxoglutarate aminotransferase activity	IEA	molecular function
GO:0005737	cytoplasm	IEA	cellular component

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)