• Gene id: 134728

Gene Summary

• Gene Symbol: IRAK1BP1   Gene   UCSC   Ensembl
• Aliases: AIP70, SIMPL
• Gene name: interleukin 1 receptor associated kinase 1 binding protein 1
• Alternate names: interleukin-1 receptor-associated kinase 1-binding protein 1, ActA binding protein 3, IRAK1-binding protein 1,
• Gene location: 6q14.1 (78867485: 78979410)     Exons: 8     NC_000006.12
• OMIM: 615375

Protein Summary

• Protein general information: Q5VVH5  
  • Name: Interleukin 1 receptor associated kinase 1 binding protein 1 (IRAK1 binding protein 1)
  • Length: 260  
  • Mass: 29106
• Sequence:

  MSLQKTPPTRVFVELVPWADRSRENNLASGRETLPGLRHPLSSTQAQTATREVQVSGTSEVSAGPDRAQVVVRVS
  STKEAAAEAKKSVCRRLDYITQSLQQQGVQAENITVTKDFRRVENAYHMEAEVCITFTEFGKMQNICNFLVEKLD
  SSVVISPPQFYHTPGSVENLRRQACLVAVENAWRKAQEVCNLVGQTLGKPLLIKEEETKEWEGQIDDHQSSRLSS
  SLTVQQKIKSATIHAASKVFITFEVKGKEKRKKHL

• Structural information:
  • Interpro: IPR007497  IPR030312  
  • STRING: ENSP00000358956
• Other Databases: GeneCards:  IRAK1BP1  Malacards:  IRAK1BP1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0007249	I-kappaB kinase/NF-kappaB signaling	ISS	biological process
GO:0006955	immune response	IEA	biological process
GO:0007249	I-kappaB kinase/NF-kappaB signaling	IEA	biological process
GO:0005634	nucleus	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0007249	I-kappaB kinase/NF-kappaB signaling	IBA	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0007249	I-kappaB kinase/NF-kappaB signaling	IEA	biological process
GO:0005634	nucleus	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)