• Gene id: 131965

Gene Summary

• Gene Symbol: METTL6   Gene   UCSC   Ensembl
• Gene name: methyltransferase like 6
• Alternate names: tRNA N(3)-methylcytidine methyltransferase METTL6, methyltransferase-like protein 6,
• Gene location: 3p25.1 (15427579: 15381274)     Exons: 17     NC_000003.12

Protein Summary

• Protein general information: Q8TCB7  
  • Name: tRNA N(3) methylcytidine methyltransferase METTL6 (EC 2.1.1. ) (Methyltransferase like protein 6)
  • Length: 284  
  • Mass: 33251
• Sequence:

  MASLQRKGLQARILTSEEEEKLKRDQTLVSDFKQQKLEQEAQKNWDLFYKRNSTNFFKDRHWTTREFEELRSCRE
  FEDQKLTMLEAGCGVGNCLFPLLEEDPNIFAYACDFSPRAIEYVKQNPLYDTERCKVFQCDLTKDDLLDHVPPES
  VDVVMLIFVLSAVHPDKMHLVLQNIYKVLKPGKSVLFRDYGLYDHAMLRFKASSKLGENFYVRQDGTRSYFFTDD
  FLAQLFMDTGYEEVVNEYVFRETVNKKEGLCVPRVFLQSKFLKPPKNPSPVVLGLDPKS

• Structural information:
  • Interpro: IPR013217  IPR026113  IPR029063  
  • STRING: ENSP00000407613
• Other Databases: GeneCards:  METTL6  Malacards:  METTL6

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0016740	transferase activity	IEA	molecular function
GO:0032259	methylation	IEA	biological process
GO:0008033	tRNA processing	IEA	biological process
GO:0008168	methyltransferase activity	IEA	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0030488	tRNA methylation	IEA	biological process
GO:0052735	tRNA (cytosine-3-)-methyltransferase activity	IEA	molecular function

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)