• Gene id: 131890

Gene Summary

• Gene Symbol: GRK7   Gene   UCSC   Ensembl
• Aliases: GPRK7
• Gene name: G protein-coupled receptor kinase 7
• Alternate names: rhodopsin kinase GRK7, g protein-coupled receptor kinase GRK7, rhodopsin kinase,
• Gene location: 3q23 (141763123: 141818489)     Exons: 6     NC_000003.12
• Gene summary(Entrez): This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. It is specifically expressed in the retina and the encoded protein has been shown to phosphorylate con
• OMIM: 300478

Protein Summary

• Protein general information: Q8WTQ7  
  • Name: Rhodopsin kinase GRK7 (EC 2.7.11.14) (G protein coupled receptor kinase 7) (G protein coupled receptor kinase GRK7)
  • Length: 553  
  • Mass: 62212
  • Tissue specificity: Retinal cones, outer and inner segments. {ECO
• Sequence:

  MVDMGALDNLIANTAYLQARKPSDCDSKELQRRRRSLALPGLQGCAELRQKLSLNFHSLCEQQPIGRRLFRDFLA
  TVPTFRKAATFLEDVQNWELAEEGPTKDSALQGLVATCASAPAPGNPQPFLSQAVATKCQAATTEEERVAAVTLA
  KAEAMAFLQEQPFKDFVTSAFYDKFLQWKLFEMQPVSDKYFTEFRVLGKGGFGEVCAVQVKNTGKMYACKKLDKK
  RLKKKGGEKMALLEKEILEKVSSPFIVSLAYAFESKTHLCLVMSLMNGGDLKFHIYNVGTRGLDMSRVIFYSAQI
  ACGMLHLHELGIVYRDMKPENVLLDDLGNCRLSDLGLAVEMKGGKPITQRAGTNGYMAPEILMEKVSYSYPVDWF
  AMGCSIYEMVAGRTPFKDYKEKVSKEDLKQRTLQDEVKFQHDNFTEEAKDICRLFLAKKPEQRLGSREKSDDPRK
  HHFFKTINFPRLEAGLIEPPFVPDPSVVYAKDIAEIDDFSEVRGVEFDDKDKQFFKNFATGAVPIAWQEEIIETG
  LFEELNDPNRPTGCEEGNSSKSGVCLLL

• Structural information:
  • Protein Domains: (56..17-)
    (/note="RGS-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00171-)
    (191..45-)
    (/note="Protein-kinase)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00159-)
    (455..52-)
    (/note="AGC-kinase-C-terminal")
  • Interpro: IPR000961  IPR000239  IPR011009  IPR000719  IPR017441   IPR016137  IPR036305  IPR008271  
  • Prosite: PS51285 PS00107 PS50011 PS00108 PS50132
  • STRING: ENSP00000264952
• Other Databases: GeneCards:  GRK7  Malacards:  GRK7

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0050254	rhodopsin kinase activity	IDA	molecular function
GO:0046777	protein autophosphorylation	IMP	biological process
GO:0007165	signal transduction	IEA	biological process
GO:0004672	protein kinase activity	IEA	molecular function
GO:0004674	protein serine/threonine kinase activity	IEA	molecular function
GO:0004703	G protein-coupled receptor kinase activity	IEA	molecular function
GO:0005524	ATP binding	IEA	molecular function
GO:0006468	protein phosphorylation	IEA	biological process
GO:0007601	visual perception	IEA	biological process
GO:0016740	transferase activity	IEA	molecular function
GO:0050896	response to stimulus	IEA	biological process
GO:0016301	kinase activity	IEA	molecular function
GO:0005524	ATP binding	IEA	molecular function
GO:0016310	phosphorylation	IEA	biological process
GO:0016020	membrane	IEA	cellular component
GO:0000166	nucleotide binding	IEA	molecular function
GO:0004674	protein serine/threonine kinase activity	IEA	molecular function
GO:0050254	rhodopsin kinase activity	IEA	molecular function
GO:0022400	regulation of rhodopsin mediated signaling pathway	TAS	biological process
GO:0097381	photoreceptor disc membrane	TAS	cellular component
GO:0016020	membrane	IEA	cellular component

KEGG pathways

Pathway id	Pathway name
hsa04144	Endocytosis
hsa04062	Chemokine signaling pathway
hsa04744	Phototransduction

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881