• Gene id: 130535

Gene Summary

• Gene Symbol: KCTD18   Gene   UCSC   Ensembl
• Aliases: 6530404F10Rik
• Gene name: potassium channel tetramerization domain containing 18
• Alternate names: BTB/POZ domain-containing protein KCTD18, potassium channel tetramerisation domain containing 18,
• Gene location: 2q33.1 (200510067: 200488957)     Exons: 7     NC_000002.12

Protein Summary

• Protein general information: Q6PI47  
  • Name: BTB/POZ domain containing protein KCTD18
  • Length: 426  
  • Mass: 46739
• Sequence:

  MEGHKAEEEVLDVLRLNVGGCIYTARRESLCRFKDSMLASMFSGRFPLKTDESGACVIDRDGRLFKYLLDYLHGE
  VQIPTDEQTRIALQEEADYFGIPYPYSLSDHLANEMETYSLRSNIELKKALTDFCDSYGLVCNKPTVWVLHYLNT
  SGASCESRIIGVYATKTDGTDAIEKQLGGRIHSKGIFKREAGNNVQYIWSYYSVAELKKMMDAFDAWEGKGVSYW
  RVPHELIECWTLEERPLLGSLRHMAPIRKRRLITFNEADESVNYKTGPKPVRFLGPSTSTQIKVKNSASVTVSPA
  SAIQTSAGATANRFQSGSRRKAAQRSAPSRATALVGTGAPGHPQASPGAASAENGGTHLPPAKVLLSDKKPTPQR
  VIKLKRTPLCATAPCLPSPTATRQANSLKPLPGEAARALGVRTENGKNKGN

• Structural information:
  • Protein Domains: (12..8-)
    (/note="BTB"-)
  • Interpro: IPR011333  IPR003131  
  • STRING: ENSP00000352941
• Other Databases: GeneCards:  KCTD18  Malacards:  KCTD18

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0051260	protein homooligomerization	IEA	biological process

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881