• Gene id: 129285

Gene Summary

• Gene Symbol: PPP1R21   Gene   UCSC   Ensembl
• Aliases: CCDC128, KLRAQ1
• Gene name: protein phosphatase 1 regulatory subunit 21
• Alternate names: protein phosphatase 1 regulatory subunit 21, KLRAQ motif containing 1, KLRAQ motif-containing protein 1, coiled-coil domain containing 128, coiled-coil domain-containing protein 128,
• Gene location: 2p16.3 (48440765: 48515391)     Exons: 24     NC_000002.12
• OMIM: 618159

Protein Summary

• Protein general information: Q6ZMI0  
  • Name: Protein phosphatase 1 regulatory subunit 21 (Coiled coil domain containing protein 128) (KLRAQ motif containing protein 1)
  • Length: 780  
  • Mass: 88314
• Sequence:

  MASAELQGKYQKLAQEYSKLRAQNQVLKKGVVDEQANSAALKEQLKMKDQSLRKLQQEMDSLTFRNLQLAKRVEL
  LQDELALSEPRGKKNKKSGESSSQLSQEQKSVFDEDLQKKIEENERLHIQFFEADEQHKHVEAELRSRLATLETE
  AAQHQAVVDGLTRKYMETIEKLQNDKAKLEVKSQTLEKEAKECRLRTEECQLQLKTLHEDLSGRLEESLSIINEK
  VPFNDTKYSQYNALNVPLHNRRHQLKMRDIAGQALAFVQDLVTALLNFHTYTEQRIQIFPVDSAIDTISPLNQKF
  SQYLHENASYVRPLEEGMLHLFESITEDTVTVLETTVKLKTFSEHLTSYICFLRKILPYQLKSLEEECESSLCTS
  ALRARNLELSQDMKKMTAVFEKLQTYIALLALPSTEPDGLLRTNYSSVLTNVGAALHGFHDVMKDISKHYSQKAA
  IEHELPTATQKLITTNDCILSSVVALTNGAGKIASFFSNNLDYFIASLSYGPKAASGFISPLSAECMLQYKKKAA
  AYMKSLRKPLLESVPYEEALANRRILLSSTESREGLAQQVQQSLEKISKLEQEKEHWMLEAQLAKIKLEKENQRI
  ADKLKNTGSAQLVGLAQENAAVSNTAGQDEATAKAVLEPIQSTSLIGTLTRTSDSEVPDVESREDLIKNHYMARI
  VELTSQLQLADSKSVHFYAECRALSKRLALAEKSKEALTEEMKLASQNISRLQDELTTTKRSYEDQLSMMSDHLC
  SMNETLSKQREEIDTLKMSSKGNSKKNKSR

• Structural information:
  • Interpro: IPR019348  IPR040024  IPR019343  
  • STRING: ENSP00000294952
• Other Databases: GeneCards:  PPP1R21  Malacards:  PPP1R21

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005769	early endosome	IDA	cellular component
GO:0005768	endosome	IEA	cellular component
GO:0005769	early endosome	IEA	cellular component
GO:0016020	membrane	HDA	cellular component

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881