• Gene id: 127255

Gene Summary

• Gene Symbol: LRRIQ3   Gene   UCSC   Ensembl
• Aliases: LRRC44
• Gene name: leucine rich repeats and IQ motif containing 3
• Alternate names: leucine-rich repeat and IQ domain-containing protein 3, leucine rich repeat containing 44, leucine-rich repeat-containing protein 44,
• Gene location: 1p31.1 (74198200: 74026014)     Exons: 9     NC_000001.11
• OMIM: 617957

Protein Summary

• Protein general information: A6PVS8  
  • Name: Leucine rich repeat and IQ domain containing protein 3 (Leucine rich repeat containing protein 44)
  • Length: 624  
  • Mass: 73675
• Sequence:

  MFHGTVTEELTSHEEWSHYNENIREGQKDFVFVKFNGLHLKSMENLQSCISLRVCIFSNNFITDIHPLQSCIKLI
  KLDLHGNQIKSLPNTKFWNGLKNLKLLYLHDNGFAKLKNICVLSACPTLIALTMFDCPVSLKKGYRHVLVNSIWP
  LKALDHHVISDEEIIQNWHLPERFKACNHRLFFNFCPALRKGTTYEEEINNIKHITSKINAILAHNSPVLIVQRW
  IRGFLVRKNLSPVFFHKKKQQEKIIRGYEAKWIYITKGYEDKLLKDLFFKPETNIKGKLAYWKHNIYYPVDLKNS
  SEHRKHVSSILCELKPKDLGMKSKTSRHLIQKGQESEDEIVDEKLDTSFRISVFKLPIYTSGSLKNNAVLREKKQ
  HFFPAYPQPIYTTHPKPIIKKDIRLERSMKEFFAPQRAGMKLRTFSDIDKYYTEQKKQEYHKEKVRVVAMAQVAR
  ERVRVAVNEHLNQKKYATQKLIEENKETIQNSLRQVWQNRFNYLEKARERKALFLKEKSQKASERLLVQNLNNER
  TLLTRGLLKIDRLEKNEAVLKEKSLIVKQKLKAEKYRKNLLKEMKKVRSQEIYKRHCEEKFVMDMIAFEKACERL
  QDAKTKVAIVKTNLDFKVPNGLIK

• Structural information:
  • Protein Domains: (132..17-)
    (/note="LRRCT-)
    (215..24-)
    (/note="IQ-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00116"-)
  • Interpro: IPR000048  IPR001611  IPR025875  IPR032675  
  • Prosite: PS50096 PS51450
  • STRING: ENSP00000346414
• Other Databases: GeneCards:  LRRIQ3  Malacards:  LRRIQ3

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881