• Gene id: 126820

Gene Summary

• Gene Symbol: DNAI3   Gene   UCSC   Ensembl
• Aliases: DIC3, NYD-SP29, WDR63
• Gene name: dynein axonemal intermediate chain 3
• Alternate names: WD repeat-containing protein 63, WD repeat domain 63, testicular tissue protein Li 225, testis development protein NYD-SP29 (NYD-SP29),
• Gene location: 1p22.3 (85062297: 85133137)     Exons: 23     NC_000001.11
• OMIM: 617968

Protein Summary

• Protein general information: Q8IWG1  
  • Name: WD repeat containing protein 63 (Testis development protein NYD SP29)
  • Length: 891  
  • Mass: 102935
• Sequence:

  MAPKQKKKTSRGKKRLKPVLAASEDMEPVNMESMGHPEIYPLVLTTKTQEIFNCRIDEDVTDEQPYKLINKEDIF
  EDLRNRAAVSDFHPVKKIVQEYPGNELLLVYDKDFKYGLNFYLIATEEGKENYLNPPEVPEEQEEYKEHIPEDVY
  IYKPPVSKPWVSLGSEKEIEEESVTESTKQITYMISRKRSEFGAPIKFSDQNASSVKDAYIECTAYPDKNFTLKQ
  LEKDVGMQVIPQIKDISTQTKWTYPKNATTQYYPREFSEEEKETLKQSKPLVDFLNNASISVEIALQQNEIMNTF
  IDDWKYLAEEEGTFGDKTDTHLKEYQSFTDLHSPTEKMITCVSWHPTIYGLIAVSVAVRLSFEDRVHFSGKLLLQ
  PSLILFWSFSDPIHPQLMLESPDDIFCFKFCPSDPNIIAGGCINGQIVMWDITAHADRIENIKAGGSRSKRATLK
  PMFLLEPESNKEAMYIRHCAVSSIENGHKKVITDIHWLSDTFEINRMGSVFENRSGICCQLVTCSADCTICFWDI
  RPQKPLTPQTTEKKKEESIEIPFDVPSTFLHLDLSWKPLTKVRLSKGETSLDHCPTKISLNEDHLLCKTQDKMLA
  QSKTEKAEEMNPYHNLESGMANLLKPIDDFCTKFFVGTEEGEVIYTDWKMEKDPETGRLMSKKPVSHHTIHDGTV
  HTIQRSPFYNDIILTVGGWNVAIWKEGVMTGPLLQSCCAPKRYTSGHWSLTRPGVFYIGREDGYIDIWDLLEKTH
  EPAQSQNICITMITYIKPWIFSSKQQFIATADYYGTLHILEIPWTLSRPSTNEMASVNHYFEREVKHLEYVEQRK
  KIREQEKKEMELEMAKKKVKTYQKSKEQMQAELKMDYESYLELEKTVLINLGLIKVTEKGSYMEVM

• Structural information:
  • Interpro: IPR015943  IPR001680  IPR036322  
  • Prosite: PS00678
  • STRING: ENSP00000294664
• Other Databases: GeneCards:  DNAI3  Malacards:  DNAI3

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0045504	dynein heavy chain binding	IBA	molecular function
GO:0060294	cilium movement involved in cell motility	IBA	biological process
GO:0007018	microtubule-based movement	IBA	biological process
GO:0036156	inner dynein arm	IBA	cellular component
GO:0036159	inner dynein arm assembly	IBA	biological process
GO:0045503	dynein light chain binding	IBA	molecular function

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881